23171-70-2Relevant academic research and scientific papers
Robust continuous-flow synthesis of deuterium-labeled ￠-nitroalcohols catalyzed by basic anion exchange resin
Cui, Sunliang,Ito, Naoya,Masuda, Hayato,Park, Kwihwan,Sajiki, Hironao,Teranishi, Wataru,Yamada, Tsuyoshi
, p. 1000 - 1006 (2020/09/22)
A practical and efficient continuous-flow system was developed for the synthesis of site-selectively deuterium-labeled ￠- nitroalcohols by using the tertiary amine-functionalized basic anion exchange resin, WA30, as a heterogeneous organocatalyst. For this system, WA30 was prepacked in a cartridge under metal-free conditions. The system was operated by pumping a solution of aldehydes or ketones, as electrophiles, and nitroalkanes in a solvent system of deuterium oxide and THF in the catalyst cartridge. Various deuterated ￠-nitroalcohols were obtained in moderate to excellent yields with high deuteration efficiencies. The continuous-flow system was applied in continuous synthesis for at least 72 h without degradation of the heterogeneous organocatalyst activity.
ISOMERIZATIONS OF THE NITROMETHANE RADICAL CATION IN THE GAS PHASE.
Egsgaard,Carlsen,Elbel
, p. 369 - 374 (2007/10/02)
The concurrent isomerizations of the nitromethane radical cation to its aci-nitromethane and methylnitrite isomers, respectively, has been established based on metastable ion studies and collision activation mass spectrometry. The energy diagram for the ionized nitromethane/aci-nitromethane tautomeric system has been determined; the aci-nitromethane tautomer was found to be the more stable species by ca. 0. 95 eV. Attempts to generate the neutral gaseous aci-nitromethane tautomer by low pressure pyrolysis are summarized.
