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N-(5-Amino-2-hydroxyphenyl)acetamide, also known as 5-aminosalicylic acid or mesalazine, is a medication primarily used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. It is an aminosalicylate derivative of salicylic acid that functions by reducing inflammation in the colon. N-(5-Amino-2-hydroxyphenyl)acetamide is administered orally or rectally and is considered a relatively safe and effective treatment for these conditions.

23184-60-3

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23184-60-3 Usage

Uses

Used in Pharmaceutical Industry:
N-(5-Amino-2-hydroxyphenyl)acetamide is used as an anti-inflammatory agent for the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. It is effective in reducing inflammation in the colon, providing relief to patients suffering from these conditions.
N-(5-Amino-2-hydroxyphenyl)acetamide works by inhibiting the production of prostaglandins and leukotrienes, both of which play a significant role in the inflammatory response. This mechanism of action contributes to its therapeutic efficacy in managing the symptoms and progression of inflammatory bowel diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 23184-60-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,1,8 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 23184-60:
(7*2)+(6*3)+(5*1)+(4*8)+(3*4)+(2*6)+(1*0)=93
93 % 10 = 3
So 23184-60-3 is a valid CAS Registry Number.

23184-60-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(5-Amino-2-hydroxyphenyl)acetamide

1.2 Other means of identification

Product number -
Other names 2-acetylamino-4-aminophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23184-60-3 SDS

23184-60-3Relevant academic research and scientific papers

Caffeic acid derivatives: A new type of influenza neuraminidase inhibitors

Xie, Yuanchao,Huang, Bing,Yu, Kexiang,Shi, Fangyuan,Liu, Tianqi,Xu, Wenfang

supporting information, p. 3556 - 3560 (2013/07/04)

Recently, many natural products, especially some plant-derived polyphenols have been found to exert antiviral effects against influenza virus and show inhibitory activities on neuraminidases (NAs). In our research, we took caffeic acid which contained two phenolic hydroxyl groups as the basic fragment to build a small compound library with various structures. The enzyme inhibition result indicated that some compounds exhibited moderate activities against NA and compound 15d was the best with IC50 = 7.2 μM and 8.5 μM against N2 and N1 NAs, respectively. The 3,4-dihydroxyphenyl group from caffeic acid was important for the activity according to the docking analysis. Besides, compound 15d was found to be a non-competitive inhibitor with Ki = 11.5 ± 0.25 μM by the kinetic study and also presented anti-influenza virus activity in chicken embryo fibroblast cells. It seemed promising to discover more potent NA inhibitors from caffeic acid derivatives to cope with influenza virus.

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