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23205-90-5

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23205-90-5 Usage

General Description

2,5-bis[(2-chloroethyl)amino]cyclohexa-2,5-diene-1,4-dione, also known as mechlorethamine, is a chemical compound with potent alkylating properties. It is commonly used as a chemotherapeutic agent for the treatment of various types of cancer, including Hodgkin's disease, non-Hodgkin lymphoma, and certain types of leukemia. Mechlorethamine works by interfering with the DNA synthesis of cancer cells, ultimately leading to cell death. However, it is highly toxic and can cause severe side effects, including bone marrow suppression, nausea, and vomiting. Due to its toxicity, mechlorethamine is mainly administered intravenously in a clinical setting under the supervision of a healthcare professional.

Check Digit Verification of cas no

The CAS Registry Mumber 23205-90-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,2,0 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 23205-90:
(7*2)+(6*3)+(5*2)+(4*0)+(3*5)+(2*9)+(1*0)=75
75 % 10 = 5
So 23205-90-5 is a valid CAS Registry Number.

23205-90-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-bis(2-chloroethylamino)cyclohexa-2,5-diene-1,4-dione

1.2 Other means of identification

Product number -
Other names 2,5-Bis(di-2'-chloroethylamino)-1,4-benzoquinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23205-90-5 SDS

23205-90-5Relevant articles and documents

Development of quinone analogues as dynamin GTPase inhibitors

Macgregor, Kylie A.,Abdel-Hamid, Mohammed K.,Odell, Luke R.,Chau, Ngoc,Whiting, Ainslie,Robinson, Phillip J.,McCluskey, Adam

, p. 191 - 206 (2014/08/18)

Virtual screening of the ChemDiversity and ChemBridge compound databases against dynamin I (dynI) GTPase activity identified 2,5-bis-(benzylamino)-1,4- benzoquinone 1 as a 273 ± 106 μM inhibitor. In silico lead optimization and focused library-led synthesis resulted in the development of four discrete benzoquinone/naphthoquinone based compound libraries comprising 54 compounds in total. Sixteen analogues were more potent than lead 1, with 2,5-bis-(4-hydroxyanilino)-1,4-benzoquinone (45) and 2,5-bis(4-carboxyanilino)- 1,4-benzoquinone (49) the most active with IC50 values of 11.1 ± 3.6 and 10.6 ± 1.6 μM respectively. Molecular modelling suggested a number of hydrogen bonding and hydrophobic interactions were involved in stabilization of 49 within the dynI GTP binding site. Six of the most active inhibitors were evaluated for potential inhibition of clathrin-mediated endocytosis (CME). Quinone 45 was the most effective CME inhibitor with an IC50(CME) of 36 ± 16 μM.

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