232265-98-4Relevant academic research and scientific papers
Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel
Gross, Michael F.,Castle, Neil A.,Zou, Anruo,Wickenden, Alan D.,Yu, Weifeng,Spear, Kerry L.
scheme or table, p. 3063 - 3066 (2010/01/16)
Aryl sulfonamido tetralins based on lead compound 2a were synthesized and evaluated for Kv1.5 inhibitory activity. Several compounds having IC50 values less then 0.1 μM were identified. Kv1.5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation.
