232267-73-1

Basic information

• Product Name: (S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-hept-6-enoic acid ethyl ester
• Synonyms: (S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-hept-6-enoic acid ethyl ester
• CAS NO: 232267-73-1
• Molecular Weight: 365.516
• Mol File: 232267-73-1.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-hept-6-enoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-hept-6-enoic acid ethyl ester(232267-73-1)
• EPA Substance Registry System: (S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-hept-6-enoic acid ethyl ester(232267-73-1)

Safety Data

• Hazardous Substances Data: 232267-73-1(Hazardous Substances Data)

Upstream product

• 17480-69-2 (S)-N-benzyl-1-phenylethylamine 
• 95514-62-8 (E)-ethyl hepta-2,6-dienoate 

Downstream Products

• 232267-79-7 (3S,6R)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-6-butyl-cycloheptanone 
• 232267-81-1 (3S,6R)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-6-isopropyl-cycloheptanone 
• 232267-77-5 (S)-6-[Benzyl-((S)-1-phenyl-ethyl)-amino]-cyclohept-2-enone 
• 232267-75-3 (S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-bicyclo[4.1.0]heptan-1-ol 

Relevant articles and documents

Synthesis of optically active 6-amino-2-cycloheptenone as a convenient chiral building block for the preparation of 6-alkyl-2-cycloheptenone

Optically active 6-amino-2-cycloheptenone 5 has been prepared from ethyl 2(E),6-heptadienoate where the Michael addition of a chiral amine, Ti(II)-mediated intramolecular nucleophilic acyl substitution reaction and FeCl3-mediated ring expansion are the key steps. The compound 5 undergoes highly diastereoselective conjugate addition of a Grignard reagent in the presence of a catalytic amount of Li2Cu(CN)Cl2 to provide the corresponding cis-adducts which, in turn, are converted into 6-alkyl substituted 2-cycloheptenones by treatment with p-TSA.