232272-55-8Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate
Zhu, Panhu,Ye, Wenfeng,Li, Jiaming,Zhang, Yanchun,Huang, Weijun,Cheng, Mohan,Wang, Yujun,Zhang, Yang,Liu, Huicai,Zuo, Jian
, p. 443 - 455 (2017/04/03)
A novel class of tetrahydroisoquinoline derivatives was designed and synthesized as antitumor agents and evaluated for their in vitro and in vivo biological activities. The antiproliferative activities of all the target compounds on HUVEC, MCF-7, and HT-2
Tetrahydroisoquinoline compound, preparation method and anti-tumor use
-
, (2017/10/22)
The invention relates to the field of medicinal chemistry, and in particular relates to a tetrahydroisoquinoline compound with a general formula I or II, a preparation method as well as a pharmaceutical composition and an application thereof. Pharmacodyna
Synthesis of isoquinoline alkaloids via oxidative amidation-bischler- napieralski reaction
Shankar,More, Satish S.,Madhubabu,Vembu,Syam Kumar
supporting information; experimental part, p. 1013 - 1020 (2012/06/01)
A straightforward synthesis of -keto amides by coupling primary amines with aryl dibromoethanones under oxidative amidation conditions has been developed. The -keto amides were then subjected to heterocyclodehydration reaction under Bischler-Napieralski conditions followed by aromatization with DBU provided 1-benzoyl isoquinolines in a two-stage process. Utilizing this methodology, isoquinoline alkaloids such as thalmicrinone, papavaraldine, and pulcheotine A were synthesized in excellent yields. Georg Thieme Verlag Stuttgart · New York.
