232280-19-2

Upstream product

• 232280-09-0 (S)-2-methyl-1-[(triisopropylsilyl)oxy]-3-[(trimethylsilyl)methyl]but-3-ene 
• 232280-22-7 methyl (2R)-2-methyl-3-[(1,1,1-triisopropylsilyl)oxy]propanoate 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 13154-24-0 triisopropylsilyl chloride 
• 181137-83-7 (2R,3R)-1,2-O-isopropylidene-6-[(4-methoxybenzyl)oxy]hexane-1,2,3-triol 
• 232280-10-3 (S)-3-bromomethyl-2-methyl-1-[(triisopropylsilyl)oxy]but-3-ene 

Downstream Products

• 232280-20-5 (1R,6S)-2-O-acetyl-1,4-anhydro-3,5,6-trideoxy-1-{3-[(4-methoxybenzyl)oxy]propyl}-6-methyl-2-C-methyl-5-methylene-7-O-(triisopropylsilyl)-D-xylo-heptitol 
• 232280-13-6 (1R,6S)-1,4-anhydro-3,5,6-trideoxy-1-{3-[(4-methoxybenzyl)oxy]propyl}-6-methyl-2-C-methyl-5-methylene-7-O-(triisopropylsilyl)-D-xylo-heptitol 
• 232280-12-5 (3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one 
• 232280-11-4 (2R)-5-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}pentanal 

Relevant academic research and scientific papers

Stereoselective construction of the tricyclic core of neoliacinic acid

(Chemical Equation Presented) The tricyclic core of the plant-derived sesquiterpene natural product neoliacinic acid was synthesized using a novel synthetic strategy. The pivotal synthetic transformations are construction of the key bicyclic ether-bridged intermediate by sequential deployment of metal carbenoid C-H insertion and ylide-forming reactions and installation of the lactone portion of neoliacinic acid by an acid-catalyzed intramolecular ring-opening reaction of an epoxide with a carboxylic acid.

Synthesis of the functionalised core of neoliacinic acid

An advanced intermediate in the synthesis of neoliacinic acid has been prepared, and the structure and relative stereochemistry have been confirmed by X-ray crystallography.