23241-13-6

Basic information

• Product Name: 3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
• Synonyms: 2H-Indol-2-one, 3-[2-(4-chlorophenyl)-2-oxoethyl]-1,3-dihydro-3-hydroxy-; 3-[2-(4-Chlorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
• CAS NO: 23241-13-6
• Molecular Formula: C₁₆H₁₂ClNO₃
• Molecular Weight: 301.7244
• Mol File: 23241-13-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 564°C at 760 mmHg
• Flash Point: 294.9°C
• Density: 1.4g/cm³
• Vapor Pressure: 1.47E-13mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one(23241-13-6)
• EPA Substance Registry System: 3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one(23241-13-6)

Safety Data

• Hazardous Substances Data: 23241-13-6(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 99-91-2 para-chloroacetophenone 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 62-53-3 aniline 

Downstream Products

• 183947-04-8 (E)-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one 
• 1622878-55-0 3-(4-chlorophenyl)-9-acetyl-pyridazino[3,4-b]indole 
• 1242856-84-3 6-(4-chlorophenyl)-5-(2-oxoindolin-3-yl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione 
• 1242857-14-2 6-(4-chlorophenyl)-1,3-dimethyl-5-(2-oxoindolin-3-yl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione 
• 23336-93-8 3-[2-(4-chlorophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one 
• 1154-53-6 3-(4-chloro-phenacyl)-indolin-2-one 
• 23336-93-8 (Z)-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one 

Relevant articles and documents

Synthesis and biological activity of substituted 3-acylmethylene and 3-hydroxy-2-indolones

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Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds

Molecular hybridization is considered as an effective tactic to develop drugs for the treatment of cancer. A series of novel hybrid compounds of isatin and Michael acceptor were designed and synthesized on the basis of association principle. These hybrid compounds were tested for cytotoxic potential against human cancer cell lines namely, BGC-823, SGC-7901 and NCI-H460 by MTT assay. Most compounds showed good anti-growth activities in all tested human cancer cells. SAR and QSAR analysis may provide vital information for the future development of novel anti-cancer inhibitors. Notably, compound 6a showed potent growth inhibition on BGC-823, SGC-7901 and NCI-H460 with the IC50 values of 3.6 ± 0.6, 5.7 ± 1.2, 3.2 ± 0.7 μM, respectively. Besides, colony formation assays, wound healing assays and flow cytometry analysis indicated 6a exhibited a potent anti-growth and anti-migration ability in a concentration-dependence manner through arrested cells in the G2/M phase of cell cycle. Moreover, 6a significantly repressed tumor growth in a NCI-H460 xenograft mouse model. Overall, our findings suggested isatin analogues inspired Michael acceptor may provide promising lead compounds for the development of cancer chemotherapeutics.

Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation-Michael addition-cyclization sequence under catalyst- and solvent-free conditions

A convenient catalyst-free, three-component procedure was developed for the synthesis of tetrasubstituted pyrroles under solvent-free conditions and in green solvents glycerol, PEG-200 and water. A sequential enamine-formation, Michael addition and intram