23243-10-9Relevant academic research and scientific papers
Copper hydride catalyzed reductive aldol addition/lactonization domino reactions of α,β-unsaturated diesters
Li, Zhengning,Li, Zengchang,Zhang, Zhenlei,Yuan, Lu,Jiang, Lan,Li, Zhansheng
, p. 724 - 728 (2014)
The first copper-catalyzed reductive aldol addition/lactonization domino reactions of α,β-unsaturated dicarboxylate esters with ketones were achieved in high yields. The method, which involves easily available reagents, a flexible combination of reactants, and mild conditions, provides a simple route to functionalized lactones bearing an ester group. Georg Thieme Verlag Stuttgart. New York.
Method for synthesizing β - - γ - butyrolactone ester method
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Paragraph 0040; 0041, (2017/08/25)
The invention relates to a method for synthesizing beta-ester group-gamma-butyrolactone and belongs to the technical field of chemical engineering. According to the method, a copper-phosphine complex catalyst is used for catalyzing alkyl group zinc, maleic acid diester and aldehyde or ketone for reacting and synthesizing the beta-ester group-gamma-butyrolactone; the copper-phosphine complex catalyst is formed by copper salt and organic phosphine ligands in a reaction system or a copper-phosphine complex which is prepared in advance; To the specific, the method comprises the steps of adding the alkyl group zinc into a mixing system of the aldehyde or ketone, the maleic acid diester and the copper-phosphine complex catalyst; or adding the aldehyde or ketone and the maleic acid diester into a mixing system of the alkyl group zinc and the copper-phosphine complex catalyst, and stirring for reacting for 0.25-10 hours in organic solvent at a temperature ranging from minus 30 DEG C to 50 DEG C. According to the method, the Cu complexing organic phosphine ligands are adopted as the catalyst to conduct the reaction, the alpha-C beta-ester group-gamma-butyrolactone without substituent groups is generated selectively, the application range is wide, the price of the catalyst is low, the reaction condition is mild, the reaction can be conducted at a room temperature or under a condition close to the room temperature, the after-treatment is simple, and the industrial production is facilitated.
