23246-80-2

Usage

Uses

Used in Pharmaceutical Industry:
5,7-Diacetoxy-8-methoxyflavone is used as a potential therapeutic agent for its anti-inflammatory, antioxidant, and anticancer properties. Its biological activities make it a promising candidate for the development of new pharmaceuticals targeting various health conditions.
Used in Traditional Medicine:
5,7-Diacetoxy-8-methoxyflavone is used in traditional medicine for various health conditions, although further research is needed to fully understand its therapeutic potential and safety profile. Its presence in natural plant sources makes it a valuable component in the formulation of natural health products.
Used in Drug Development:
5,7-Diacetoxy-8-methoxyflavone is used as a key component in the development of new pharmaceuticals and natural health products. Its potential biological activities and presence in various plants make it a valuable resource for researchers and pharmaceutical companies seeking to develop novel treatments and health supplements.

Upstream product

• 632-85-9 wogonin 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Activities of Wogonin Analogs and Other Flavones against Flavobacterium columnare

In our on-going pursuit to discover natural products and natural product-based compounds to control the bacterial species Flavobacterium columnare, which causes columnaris disease in channel catfish (Ictalurus punctatus), we synthesized flavone and chalcone analogs, and evaluated these compounds, along with flavonoids from natural sources, for their antibacterial activities against two isolates of F. columnare (ALM-00-173 and BioMed) using a rapid bioassay. The flavonoids chrysin (1a), 5,7-dihydroxy-4′-methoxyflavone (11), isorhamnetin (26), luteolin (27), and biochanin A (29), and chalcone derivative 8b showed strong antibacterial activities against F. columnare ALM-00-173 based on minimum inhibition concentration (MIC) results. Flavonoids 1a, 8, 11, 13 (5,4′-dihydroxy-7-methoxyflavone), 26, and 29 exhibited strong antibacterial activities against F. columnare BioMed based upon MIC results. The 24-h 50% inhibition concentration (IC50) results revealed that 27 and 29 were the most active compounds against F. columnare ALM-00-173 (IC50 of 7.5 and 8.5 mg/l, resp.), while 26 and 29 were the most toxic compound against F. columnare BioMed (IC50 of 9.2 and 3.5 mg/l, resp.). These IC50 results were lower than those obtained for wogonin against F. columnare ALM-00-173 and F. columnare BioMed (28.4 and 5.4 mg/l, resp.). However, based on MIC results, none of the compounds evaluated in this study were as active as wogonin (MIC 0.3 mg/l for each F. columnare isolate). Further modification of the wogonin structure to enhance antibacterial is of interest.