23255-41-6

Usage

Uses

Used in Biochemical Research:
S-[2-(acetylamino)ethyl] 3-oxobutanethioate is used as a reagent in biochemical research for the detection of sulfhydryl groups in proteins. Its ability to interact with these groups makes it a valuable tool for studying protein structure and function.
Used in Pharmaceutical Development:
S-[2-(acetylamino)ethyl] 3-oxobutanethioate is used as a potential therapeutic agent in the treatment of conditions such as arthritis and inflammatory bowel disease. Its anti-inflammatory properties have been studied for their potential to alleviate symptoms and improve patient outcomes.
Used in Peptide Synthesis:
In the field of organic chemistry, S-[2-(acetylamino)ethyl] 3-oxobutanethioate is used as a building block in the synthesis of peptides. Its unique structure allows for the creation of novel peptide sequences with potential applications in medicine and biotechnology.
Used in Cosmetic and Personal Care Products:
S-[2-(acetylamino)ethyl] 3-oxobutanethioate is used as an ingredient in cosmetic and personal care products due to its ability to regulate skin hydration and protect against UV-induced damage. Its inclusion in these products contributes to improved skin health and appearance.

InChI:InChI=1/C8H13NO3S/c1-6(10)5-8(12)13-4-3-9-7(2)11/h3-5H2,1-2H3,(H,9,11)

Upstream product

• 463-51-4 Ketene 
• 1190-73-4 2-(acetylamino)ethanethiol 
• 40053-29-0 S-phenyl 3-oxobutanethioate 
• 72324-39-1 5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 1420-88-8 S-[2-(acetylamino)ethyl] ethanethioate 
• 2633-66-1 2-mesitylmagnesium bromide 

Downstream Products

• 67024-17-3 (R)-3-Hydroxy-thiobutyric acid S-(2-acetylamino-ethyl) ester 
• 1190-73-4 2-(acetylamino)ethanethiol 
• 541-50-4 2-acetoacetic acid 

Relevant academic research and scientific papers

Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β- D -hydroxyacyl intermediates in enediyne core biosynthesis

PKSE biosynthesizes an enediyne core precursor from decarboxylative condensation of eight malonyl-CoAs. The KR domain of PKSE is responsible for iterative β-ketoreduction in each round of polyketide chain elongation. KRs from selected PKSEs were investiga

Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks

Chiral building blocks are valuable intermediates in the syntheses of natural products and pharmaceuticals. A scalable chemoenzymatic route to chiral diketides has been developed that includes the general synthesis of α-substituted, β-ketoacyl N-acetylcysteamine thioesters followed by a biocatalytic cycle in which a glucose-fueled NADPH-regeneration system drives reductions catalyzed by isolated modular polyketide synthase (PKS) ketoreductases (KRs). To identify KRs that operate as active, stereospecific biocatalysts, 11 isolated KRs were incubated with 5 diketides and their products were analyzed by chiral chromatography. KRs that naturally reduce small polyketide intermediates were the most active and stereospecific toward the panel of diketides. Several biocatalytic reactions were scaled up to yield more than 100 mg of product. These syntheses demonstrate the ability of PKS enzymes to economically and greenly generate diverse chiral building blocks on a preparative scale.