23256-23-7

Basic information

• Product Name: sulfatroxazole
• Synonyms: sulfatroxazole;SULPHATROXAZOLE;4-Amino-N-(4,5-dimethyl-3-isoxazolyl)benzenesulfonamide;N-(4,5-Dimethyl-3-isoxazolyl)-4-aminobenzenesulfonamide;N-(4,5-Dimethylisoxazole-3-yl)-4-aminobenzenesulfonamide;BenzenesulfonaMide, 4-aMino-N-(4,5-diMethyl-3-isoxazolyl)-
• CAS NO: 23256-23-7
• Molecular Formula: C₁₁H₁₃N₃O₃S
• Molecular Weight: 267.3
• EINECS: 245-530-5
• Mol File: 23256-23-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 193-195.5 °C
• Boiling Point: 484.9°Cat760mmHg
• Flash Point: 247.1°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 1.47E-09mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 5.93±0.50(Predicted)
• CAS DataBase Reference: sulfatroxazole(CAS DataBase Reference)
• NIST Chemistry Reference: sulfatroxazole(23256-23-7)
• EPA Substance Registry System: sulfatroxazole(23256-23-7)

Safety Data

• Hazardous Substances Data: 23256-23-7(Hazardous Substances Data)

Usage

Uses

Sulfatroxazole is a component present in various veterinary drugs. Possible antibacterial activity due to presence of sulfonamide moiety in the structure.

InChI:InChI=1/C11H13N3O3S/c1-7-8(2)17-13-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)

Upstream product

• 13999-39-8 4,5-dimethyl-1,2-oxazol-3-amine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 174078-98-9 DIV₀₁₃₈₉ 
• 91960-06-4 3-(N⁴-Acetylsulfanilamino)-4,5-dimethylisoxazol 

Relevant articles and documents

Design, Synthesis, and Cytotoxic Activity of Novel Natural Arylsulfonamide-Inspired Molecules

Primary arylsulfonamide functional groups feature prominently in diverse pharmaceuticals. However, natural arylsulfonamides are relatively infrequent. In this work, two novel arylsulfonamide natural products were first synthesized, and then a series of novel molecules derived from natural arylsulfonamides were designed and synthesized, and their in vitro cytotoxic activities against A875, HepG2, and MARC145 cell lines were systematically evaluated. The results indicate that some of these arylsulfonamide derivatives exhibit significantly good cytotoxic activity against the tested cell lines compared with the control 5-fluorouracil (5-FU), such as compounds 10l, 10p, 10q, and 10r. In particular, the potential molecule 10q, containing a carbazole moiety, exhibited the highest inhibitory activity against all tested cell lines, with IC50 values of 4.19 ± 0.78, 3.55 ± 0.63, and 2.95 ± 0.78 μg/mL, respectively. This will offer the potential to discover novel drug-like compounds from the sparsely populated area of natural products that can lead to effective anticancer agents.

Discovery and synthesis of a potent sulfonamide ET(B) selective antagonist

The synthesis and structure-activity relationships of a series of sulfonamide endothelin antagonists are described. In the course of our modification studies, we discovered ET(B) selective antagonists. The most potent compound 15f displays IC50 values of 1.7 μM and 0.002 μM to ET(A) and ET(B) receptors, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.