232595-07-2

Upstream product

• 232595-00-5 methyl (E)-4-(2-nitroprop-1-en-1-yl)benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 952751-35-8 methyl 4-(3-methyl-3-nitrooxiran-2-yl)benzoate 
• 232595-03-8 methyl 4-(2-{[amino(imino)methyl]amino}-4-methyl-1,3-thiazol-5-yl)benzoate 

Downstream Products

• 952750-64-0 N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine 
• 232595-27-6 ethyl rac 3-[4-(2-guanidino-4-methyl-thiazol-5-yl)-benzoylamino]-3-phenyl-propionate 

Relevant academic research and scientific papers

THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES

This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Di

Thiazole derivatives

Compounds of the formula: as well as pharmaceutically usable salts and esters thereof, wherein R1, R2and R3have the significance ascribed herein, inhibit binding of adhesive proteins to the surface of different types of cell and accordingly influence cell-cell and cell-matrix interactions. These compounds can be used in the form of pharmaceutical preparations for the control or prevention of neoplasms, tumor metastasing, tumor growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure, as well as infection caused by viruses, bacteria or fungi.

Thiazole derivatives

Compounds of the formula: as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance ascribed herein, inhibit binding of adhesive proteins to the surface of different types of cell and accordingly influence cell-cell and cell-matrix interactions. These compounds can be used in the form of pharmaceutical preparations for the control or prevention of neoplasms, tumor metastasing, tumor growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure, as well as infection caused by viruses, bacteria or fungi.