23286-28-4

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1080-44-0 N-Tosylglycine 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 83800-76-4 1-(p-Toluenesulphonyl)-2-hydantoin 
• 394220-78-1 (Z)-5-(4-dimethylaminobenzylidene)-1-(4-methylphenylsulfonyl)-2-thiohydantoin 
• 394220-77-0 (Z)-5-(4-methoxybenzylidene)-1-(4-methylphenylsulfonyl)-2-thiohydantoin 

Relevant academic research and scientific papers

Chiral aryl sulfonyl hydantoins as hypoglycemic agents

Some novel chiral sulfonyl hydantoin derivatives 2a-e and 3a-e have been prepared. p-Toluenesulfonyl chloride on treatment with L-amino acids in presence of K2CO3/H2O yielded N-(p-toluensulfonyl-)amino acids 1a-e which were cyclized in presence of NH4SCN / Ac2O to afford 1-(p-toluenesulfonyl)-5-substituted-2-thiohydantoins 2a-e. These compounds were oxidized with HNO3 to yield 1-(p-toluenesulfonyl)-5-substituted hydantoins 3a-e. The enantiomeric ratios of 3a-e were determined by 1H NMR spectroscopy using Eu(hfc)3. The antidiabetic activity of 3a-d has been determined.