232953-64-9

Upstream product

• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 192313-40-9 3-(2-(4-methoxyphenyl)acetyl)oxazolidin-2-one 
• 139122-53-5 3-(p-methoxyphenyl)acetyl-(4S)-isopropyl-2-oxazolidinone 
• 56475-86-6 2-methoxy-piperidine-1-carboxylic acid methyl ester 
• 1796-27-6 piperidine-1-carboxylic acid methyl ester 
• 186581-53-3 diazomethane 

Relevant academic research and scientific papers

A convenient method for synthesis of optically active methylphenidate from N-methoxycarbonylpiperidine by utilizing electrochemical oxidation and Evans aldol-type reaction

A new method to prepare optically active methylphenidate starting from piperidine is described. The method consists of a transformation of N-methoxycarbonylated piperidine to the corresponding α-methoxylated carbamate utilizing electrochemical oxidation f

A convenient method for synthesis of enantiomerically enriched methylphenidate from N-methoxycarbonylpiperidine

(equation presented) This report describes a new method to prepare optically active methylphenidate starting from piperidine. The method consists of a transformation of N-methoxycarbonylpiperidine to the corresponding α-methoxylated carbamate I by utilizing electrochemical oxidation followed by the coupling reaction with optically active Evans imides II to produce optically active methylphenidate derivatives III with high stereoselectivities. threo-(2R,2′R)-Methylphenidate (IV; Ar=Ph; Ritalin) was easily prepared from III in three steps.