233-59-0

Basic information

• Product Name: 2H-naphtho[1,2-d][1,2,3]triazole
• Synonyms: 3H-naphtho[1,2-d]-1,2,3-triazole
• CAS NO: 233-59-0
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.1827
• Mol File: 233-59-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 392.8°C at 760 mmHg
• Flash Point: 193.2°C
• Density: 1.381g/cm³
• Vapor Pressure: 2.23E-06mmHg at 25°C
• Refractive Index: 1.804
• CAS DataBase Reference: 2H-naphtho[1,2-d][1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-naphtho[1,2-d][1,2,3]triazole(233-59-0)
• EPA Substance Registry System: 2H-naphtho[1,2-d][1,2,3]triazole(233-59-0)

Safety Data

• Hazardous Substances Data: 233-59-0(Hazardous Substances Data)

Usage

General Description

2H-naphtho[1,2-d][1,2,3]triazole, also known as Naphthalen-2-yl-[1,2,3]triazole, is a heterocyclic compound with a naphthalene ring fused to a triazole ring. It is commonly used in the field of organic chemistry as a building block for creating new organic compounds with potential biological activities. This chemical exhibits a high degree of stability and has been studied for its potential applications in materials science, such as in the development of organic semiconductors and optoelectronic devices. Additionally, 2H-naphtho[1,2-d][1,2,3]triazole derivatives have also shown promise as potential anti-cancer and anti-microbial agents in various research studies.

Upstream product

• 252054-88-9 1-(trimethylsilyl)naphthalen-2-yl triflate 
• 134-32-7 1-amino-naphthalene 
• 771-14-2 2-bromonaphthalen-1-amine 
• 111180-88-2 1-azido-2-bromonaphthalene 
• 606-57-5 1-nitro-2-naphthylamine 
• 938-25-0 1,2-diaminonaphthalene 
• 82424-48-4 2-acetylamino-1-naphthylamine 

Relevant articles and documents

Selective Synthesis of N-H and N-Aryl Benzotriazoles by the [3 + 2] Annulation of Sodium Azide with Arynes

The synthetic utility of NaN3 as the azide component in the [3 + 2] annulation with arynes generated from 2-(trimethylsilyl)aryltriflates resulting in the transition-metal-free synthesis of N-H and N-aryl benzotriazoles has been demonstrated. Using CsF as the fluoride source in CH3CN, the N-H benzotriazoles are formed in high selectivity instead of the expected azidobenzene. Interestingly, N-aryl benzotriazoles are formed using KF and THF as solvent in an open-flask reaction. Moreover, a method for the N1-arylation of benzotriazole is also presented.

Compounds and methods

Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinophathy, rheumatoid arthritis, atherosclerotic