23301-02-2

Upstream product

• 2655-35-8 1-(3,5-dimethylpyrazol-1-yl)-2-phenylethane 
• 103-63-9 1-phenyl-2-bromoethane 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 70-11-1 α-bromoacetophenone 
• 123-54-6 acetylacetone 
• 87581-58-6 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylethan-1-one 
• 96-09-3 styrene oxide 

Relevant academic research and scientific papers

Iridium-Catalyzed Regio- and Enantioselective Borylation of Unbiased Methylene C(sp3)?H Bonds at the Position β to a Nitrogen Center

Reported herein is the pyrazole-directed iridium-catalyzed enantioselective borylation of unbiased methylene C?H bonds at the position β to a nitrogen center. The combination of a chiral bidentate boryl ligand, iridium precursor, and pyrazole directing group was responsible for the high regio- and enantioselectivity observed. The method tolerated a vast array of functional groups to afford the corresponding C(sp3)?H functionalization products with good to excellent enantioselectivity.

Synthesis of some novel 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-arylethanols as antimicrobial agents

In search of new biologically active agents, some novel 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-arylethanols 2a-k have been synthesized and characterized on the basis of their infra-red, nuclear magnetic resonance (NMR) (1H,13C), mass spe

An efficient synthesis of β-hydroxyethylpyrazoles from propylene and styrene oxide using Cs2CO3

Bases such as caesium carbonate efficiently catalyze the regioselective ring opening of propylene and styrene oxide with various substituted pyrazoles.

Asymmetric borane reduction of ketones catalyzed by N-hydroxyalkyl-l-menthopyrazoles

The equimolar mixture of N-(hydroxyalkyl)pyrazoles and borane formed boric ester complex, in which the remaining borane was stabilized by the adjacent nitrogen of thr pyrazole ring. The borane complex derived from the chiral pyrazoles such as 3-phenyl-l-menthopyrazole reduced p-methylacetophenone (21) enantioselectively. When (2'S)-2-(2'-phenyl-2'-hydroxyethyl)-3-phenyl-l-menthopyrazole ((2'S)-10b) was used, 21 was reduced into (S)-p-methylphenyl-1-ethanol (22) in moderate chemical and optical yields. Due to the inconvenience of the preparation and the lower optical yield, the use of N-(α-hydroxyalkyl)pyrazoles was unpromising for the enantioselective reduction of ketones by borane.