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MTT formazan is a chemical compound that serves as a vital indicator in cell viability assays, reflecting the metabolic activity and proliferation of cells. It is a yellow, water-insoluble compound that, upon conversion by the mitochondrial dehydrogenase enzymes present in living cells, turns into a purple formazan product. This transformation is fundamental for assessing cell viability, as the quantity of formazan generated is directly related to the cells' metabolic activity.
Usage:
Used in Cell Biology Research:
MTT formazan is utilized as a viability indicator for assessing the metabolic activity of cells in various research applications. It is particularly instrumental in the MTT assay and MTT-based cell proliferation assays, which are employed to evaluate the impact of experimental treatments, drugs, or environmental factors on cell viability.
Used in Diagnostic Applications:
In the diagnostic industry, MTT formazan is used as a tool for determining the health and functionality of cells. It aids in identifying the effects of potential therapeutic agents or harmful substances on cellular metabolism, thereby contributing to the development of new treatments and safety assessments.
Used in Pharmaceutical Development:
MTT formazan is employed as a screening agent in the pharmaceutical industry to test the efficacy and safety of new drugs. By measuring the metabolic activity of cells exposed to these drugs, researchers can determine the potential cytotoxic effects and selectivity of drug candidates.
Used in Environmental Studies:
In environmental science, MTT formazan is used as a bioindicator to assess the impact of environmental factors or pollutants on cellular health. This helps in understanding the effects of environmental changes on living organisms and contributes to ecological risk assessments and conservation efforts.

23305-68-2

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23305-68-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 23305-68-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,3,0 and 5 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 23305-68:
(7*2)+(6*3)+(5*3)+(4*0)+(3*5)+(2*6)+(1*8)=82
82 % 10 = 2
So 23305-68-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H17N5S/c1-13-14(2)24-18(19-13)22-17(15-9-5-3-6-10-15)20-23(21-22)16-11-7-4-8-12-16/h3-12,21H,1-2H3

23305-68-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name MTT FORMAZAN

1.2 Other means of identification

Product number -
Other names 2-[3,5-di(phenyl)-2H-tetrazol-1-yl]-4,5-dimethyl-1,3-thiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23305-68-2 SDS

23305-68-2Downstream Products

23305-68-2Relevant academic research and scientific papers

Modification of mtt assay for precision and repeatability and its mechanistic implication

Wang, Xu-Dong,Deng, Rui-Cheng,Liu, Yao,Li, Biao,Huang, Shen,Ouyang, Hui,Xiao, Zhu-Ping

, p. 8015 - 8018 (2014)

The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay is an attractive method for antibiotics screening. However, a severe deviation will occur when a strong acidic sodium dodecyl sulfate is used as a lysis buffer in MTT assay and n

Studies on some metal complexes of a quinoxaline?based unsymmetrical ONNO donor ligand: Synthesis, spectral characterization, thermal, in vitro biological and DFT studies

Dhanaraj, C. Justin,Johnson, Jijo

, p. 1845 - 1862 (2017/02/10)

Abstract: Co(II), Ni(II), Cu(II) and Zn(II) complexes of an unsymmetrical tetradentate ONNO donor ligand, 3-(-(3-(-1-(2-hydroxyphenyl)ethylideneamino)propylimino)methyl)quinoxalin-2(1H)-one (L) have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, FTIR, UV–Vis., mass and 1H NMR spectral studies. ESR spectra of the Cu(II) complex under room (300?K) and liquid nitrogen temperature (77?K) were also recorded. Thermal behavior of the newly synthesized ligand and its metal complexes was assessed by TG–DTG analysis. All the complexes are found to be mononuclear. Crystallinity, average grain size and unit cell parameters were determined from powder X-ray diffraction study. Electrochemical behavior of the compounds was examined by cyclic voltammetry technique. The in vitro antimicrobial screening of the unsymmetrical ligand and corresponding metal chelates was tested against some bacterial strains (E. coli, K. pneumoniae, S. pneumoniae and S. aureus) and fungal strains (A. niger, A. flavus, P. chrysogenum and R. stolonifer). The in vitro antioxidant and anticancer activities of the compounds were also evaluated. DFT studies were done to optimize the structure of the compounds and to calculate nonlinear optical properties of the compounds. Graphical Abstract: [Figure not available: see fulltext.]

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