233268-82-1

Upstream product

• 13547-70-1 1-chloro-3,3-dimethyl-butan-2-one 
• 55041-27-5 3,3-bis[4-hydroxy-3-methylphenyl]pentane 
• 5469-26-1 1-Bromopinacolon 
• 96-22-0 pentan-3-one 
• 95-48-7 ortho-cresol 

Downstream Products

• 700832-39-9 trifluoromethanesulfonic acid 4-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethylpropyl}-2-methyl-phenyl ester 
• 259733-96-5 3'-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]-3'-[4-hydroxy-3-methylphenyl]pentane 
• 1308681-17-5 C₂₅H₃₆O₃ 
• 1308681-18-6 C₂₅H₃₆O₃ 
• 512198-03-7 bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester 
• 512198-02-6 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxy]-3,3-dimethyl-butan-2-ol 
• 512198-00-4 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxy]-3,3-dimethyl-butan-2-one 
• 512198-01-5 1-[4-(1-{4-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxy]-3,3-dimethyl-butan-2-ol 
• 512197-99-8 1-[4-(1-{4-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxy]-3,3-dimethyl-butan-2-one 

Relevant academic research and scientific papers

(2S,2′R)-Analogue of LG190178 is a major active isomer

Vitamin D receptor (VDR) ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. VDR ligands also show immense potential as therapeutic agents for autoimmune diseases and cancers of the skin, prostat

Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators

The present invention relates to a method of treating or preventing damage to human skin cells by chemical vesicants by administering a non-secosteroidal, diphenyl compound with vitamin D receptor (VDR) modulating activity.

VITAMIN D RECEPTOR MODULATORS

The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis. X-15439

VITAMIN D RECEPTOR MODULATORS

The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

Affinity labeling of the nuclear vitamin D receptor with nonsteroidal alkylating agents.

Synthesis of an affinity alkylating non steroidal mimic of 1alpha,25-dihydroxyvitamin D(3) and its radiolabeled counterpart is presented. We also report the affinity labeling of the VDR-ligand binding domain (VDR-LBD) with this analogue.