233271-65-3Relevant academic research and scientific papers
Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/FcεRI receptor mediated mast cell leukotriene release
Venkatachalam,Qazi,Samuel,Uckun
, p. 1095 - 1105 (2003)
Mast cell derived leukotrienes (LT's) play a vital role in pathophysiology of allergy and asthma. We synthesized various analogues of indolyl, naphthyl and phenylethyl substituted halopyridyl, thiazolyl and benzothiazolyl thioureas and examined their in vitro effects on the high affinity IgE receptor/FcεRI-mediated mast cell leukotriene release. Of the 22 naphthylethyl thiourea compounds tested, there were 7 active compounds and N-[1-(1-naphthyl)ethyl]-N′-[2-(ethyl-4-acetylthiazolyl)]thiourea (17 and 16) (IC50=0.002 μM) and N-[1-(1R)-naphthylethyl]-N′-[2-(5-methylpyridyl)]thiourea (compound 5) (IC50=0.005 μM) were identified as the lead compounds. Among the 11 indolylethyl thiourea compounds tested, there were seven active compounds and the halopyridyl compounds N-[2-(3-indolylethyl)]-N′-[2-(5-chloropyridyl)]thiourea (24) and N-[2-(3-indolylethyl)]-N′-[2-(5-bromopyridyl)]thiourea (25) were the most active agents and inhibited the LTC4 release with low micromolar IC50 values of 4.9 and 6.1 μM, respectively. The hydroxylphenyl substituted compounds N-[2-(4-hydroxyphenyl)ethyl]-N′-[2-(5-chloropyridyl)]thiourea (37; IC50=12.6 μM), N-[2-(4-hydroxyphenyl)ethyl]-N′-[2-(5-bromopyridyl)]thiourea (50; IC50=16.8 μM) and N-[2-(4-hydroxyphenyl)ethyl]-N′-[2-(pyridyl)]thiourea (35; IC50=8.5 μM) were the most active pyridyl thiourea agents. Notably, the introduction of electron withdrawing or donating groups had a marked impact on the biological activity of these thiourea derivatives and the Hammett sigma values of their substituents were identified as predictors of their potency. In contrast, experimentally determined partition coefficient values did not correlate with the biological activity of the thiourea compounds which demonstrates that their liphophilicity is not an important factor controlling their mast cell inhibitory effects. These results establish the substituted halopyridyl, indolyl and naphthyl thiourea compounds as a new chemical class of anti-allergic agents inhibiting IgE receptor/FcεRI-mediated mast cell LTC4 release. Further lead optimization efforts may provide the basis for new and effective treatment as well as prevention programs for allergic asthma in clinical settings.
NNI for treatment of multi-drug resistant HIV
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Page/Page column 14-15, (2008/06/13)
The present invention is directed to compounds and methods suitable for the treatment of HIV infection.
