233272-34-9Relevant articles and documents
Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: Cholesterol acyltransferase and lipid peroxidation
Ohta, Masaru,Takahashi, Kenji,Kasai, Masayasu,Shoji, Yoshimichi,Kunishiro, Kazuyoshi,Miike, Tomohiro,Kanda, Mamoru,Mukai, Chisato,Shirahase, Hiroaki
experimental part, p. 1066 - 1076 (2010/11/16)
To find a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with anti-lipid peroxidative activity, a series of tetrahydroisoquinoline derivatives were synthesized and evaluated. A compound with a N-(4-hydroxy-2,3,5-trimethylphenyl)carbamoyl moi
TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF
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Page/Page column 45, (2010/11/28)
The present invention provide a tetrahydroisoquinoline compound having a superior ACAT-inhibitory activity and/or anti-oxidation action, particularly, novel compound represented by the formula (I) (wherein each symbol is as described in the specification) and a pharmaceutically acceptable salt thereof.