23340-29-6Relevant academic research and scientific papers
Thioreductones and derivatives
Schank, Kurt,Buegler, Stephan,Folz, Harald,Schott, Norbert
, p. 1606 - 1649 (2008/02/09)
Replacement of one or two (principally also three) O-atoms in aci-reductones by sulfur leads to the corresponding thioreductones. In the present paper, different methods of their synthesis are discussed. Substitution of the bromo nucleofug in the 2-position of 1,3-dicarbonyl compounds as well as of a 3-oxosulfone by selected sulfur nucleophiles is assumed to follow an 5 RN1 pathway. Characteristic properties, some typical reactions, and selected derivatives were studied. 5-Alkyl- and 5-aryl-substituted cyclic 2-thioreductones have been found to be synthons for the preparation of vinylogous reductones (2,3-diacyl-1,4-dihydroxy-1,3-dienes) and of tetraacyl ethylenes as their bis-dehydro products.
