233587-74-1

Upstream product

• 302965-09-9 (2S,3S,4S,5R,6S)-3,4,5-Tris-benzoyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 5140-28-3 3-O-acetylmorphine 

Relevant academic research and scientific papers

Selective synthesis of both isomers of morphine 6-β-D-glucuronide and their analogs

A stereoselective synthesis of both isomers of the pharmaceutically important morphine 6-β-D-glucuronide (M6G) and its analogs was developed. The method is based on the use of ZnBr2 for the key coupling reaction. It was shown that the α/β stere

6-O-Glycosylation of morphine derivatives using thioglycosides as glycosyl donors

A novel approach was developed for the synthesis of the pharmaceutically important morphine and dihydromorphine 6-β-D-glucuronides. The key step involves a selective 6-O-glycosylation of 3-O-protected morphines and dihydromorphines with thioglycosides that serve as glycosyl donors in the presence of thiophilic promoters. This novel approach may be useful for the O-glycosylation of other alkoloid derivatives.