233590-33-5Relevant academic research and scientific papers
1,2,3,5-tetrahydrobenzo'c!azepin-4-one derivatives having muscarinic antagonist activity
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, (2008/06/13)
There is disclosed a compound having the formula or a pharmaceutically acceptable salt thereof, wherein: R1a, R1b and R1c are independently fluorine or hydrogen; R2 is C1 to C12 alkyl being
Synthesis of 2,3-disubstituted pyrrolidines by intramolecular addition of α-aminoalkyl radicals to electron deficient C=C bonds
Aurrecoechea, Jose M.,Fernandez, Alvaro,Gorgojo, Jose M.,Saornil, Carlos
, p. 7345 - 7362 (2007/10/03)
2,3-Disubstituted pyrrolidines are prepared by SmI2-promoted cyclization of α-amino radicals generated from N-(α- benzotriazolylakyl)alkenylamines containing a C=C bond activated by an electron withdrawing substituent. The diastereoselectivity of cyclization is moderate and depends on the nature of the substituent at the pyrrolidine 2- position.
