233596-95-7Relevant academic research and scientific papers
Enantioselective preparation of 3,4,5-trisubstituted-4,5- dihydroisoxazoles and 4-substituted-5,6-dihydro-4H-[1,2]-oxazines by nitrile oxide cycloaddition to α-silyl allyl alcohols
Kamimura, Akio,Kaneko, Yukio,Ohta, Ayaki,Kakehi, Akikazu,Matsuda, Haruhiko,Kanemasa, Shuji
, p. 4349 - 4352 (1999)
Regio- and stereoselective 1,3-dipolar cycloaddition of nitrile oxide to optically active α-silyl allyl alcohol provides a useful preparation of 3,4,5-trisubstituted 4,5-dihydroisoxazoles, which are readily converted into chiral 4-substituted 5,6-dihydro-4H-[1,2]-oxazines in 73-100% yields on treatment with TBAF.
