233604-28-9

Upstream product

• 233604-26-7 (E)-3-[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]propenoic acid methyl ester 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 874-90-8 4-methoxybenzonitrile 
• 627-63-4 fumaryl dichloride 
• 6926-51-8 5-(4-methoxyphenyl)-2H-tetrazole 

Downstream Products

• 233604-26-7 (E)-3-[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]propenoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of the e and Z isomers of 3-(5-aryl-1,3,4-oxadiazol-2-yl)acrylic acids

Two procedures have been proposed for the synthesis of pure (E)- and (Z)-3-(5-aryl-1,3,4-oxadiazol-2-yl)acrylic acids, by one-step cyclization of (Z)-4-(2-aroylhydrazinyl)-4-oxobut-2-enoic acids or via initial cyclization of (Z)-4-(2-aroylhydrazinyl)-4-oxobut-2-enoic acids to 5-(aroylhydrazinylidene)furan-2(5H)-ones which are then converted into the target compounds.

The Synthesis of (1,3,4-Oxadiazol-2-yl)Acrylic Acid Derivatives with Antibacterial and Protistocidal Activities

A series of new 1,3,4-oxadiazol-2-yl-acrylic acids was synthesized by cyclization of 4-(2-R-hydrazino)- 4-oxo-2-butenic acids, and their antibacterial and protistocidal activities were studied. The p-substituted benzyl derivatives in the Z-form were shown to exhibit a high protistocidal activity, which exceeded that of the reference drug Baycox (toltrazuril) by several times, whereas the 3-hydroxy-2-naphthyl derivative, in addition to a very high protistocidal activity, also exhibited a moderate antibacterial activity.

(E)-1,2-bis(5-aryl-1,3,4-oxadiazol-2-yl)ethenes

A series of (E)-1,2-bis(1,3,4-oxadiazol-2-yl)ethenes with a variety of aromatic substituents in the 5-positions of the heterocycles was prepared by acylation of the corresponding tetrazoles with fumaryl chloride and subsequent thermal ring transformation. The modified Huisgen reaction renders a new pathway to 3-(1,3,4-oxadiazol-2-yl)propenoic acids and subsequently to the title compounds with different substituents.