233608-05-4

Upstream product

• 180399-95-5 [1-p-Tolyl-meth-(E)-ylidene]-phosphoramidic acid diethyl ester 
• 1730-25-2 allylmagnesium bromide 
• 106-95-6 allyl bromide 

Relevant academic research and scientific papers

N-(diethoxyphosphoryl)aldimines as synthetic equivalents of A1 type synthons

Novel organophosphorus reagents useful for convergent synthesis of primary amines are presented.

Synthesis of α-arylalkylamines by addition of Grignard reagents to N- (diethoxyphosphoryl)aldimines

Addition of organomagnesium bromides to N-(diethoxyphosphoryl) aldimines 1 carded out in tetrahydrofuran at 20-25°C affords diethyl N-alkyl- phosphoramidates 2a-w in high yields and spectroscopic purity. Deprotection of the latent amino groups in 2 results in the formation of α-arylalkylamine hydrochlorides 3a-w.