233690-48-7

Upstream product

• 791602-98-7 (E)-5-phenyl-2-penten-1-yl methyl carbonate 
• 51779-32-9 iminodicarboxylic acid di-tert-butyl ester 
• 171357-71-4 N-tert-butoxycarbonyl-homophenylalanine-N'-methoxy-N'-carboxamide 
• 116611-56-4 tert-butyl (R)-(1-hydroxy-4-phenylbutan-2-yl)carbamate 

Downstream Products

• 233690-84-1 (4-tert-butoxycarbonylamino-6-{1-[(5,6-dimethyl-benzooxazol-2-yl)-hydroxy-methyl]-3-phenyl-propylamino}-5-hydroxy-hexyl)-carbamic acid tert-butyl ester 
• 233690-60-3 (4-tert-butoxycarbonylamino-4-{1-[(5,6-dimethyl-benzooxazol-2-yl)-hydroxy-methyl]-3-phenyl-propylcarbamoyl}-butyl)-carbamic acid tert-butyl ester 
• 233690-63-6 (4-tert-butoxycarbonylamino-4-{1-[(5-chloro-benzooxazol-2-yl)-hydroxy-methyl]-3-phenyl-propylcarbamoyl}-butyl)-carbamic acid tert-butyl ester 
• 233690-65-8 (4-{1-[(1H-benzoimidazol-2-yl)-hydroxy-methyl]-3-phenyl-propylcarbamoyl}-4-tert-butoxycarbonylamino-butyl)-carbamic acid tert-butyl ester 
• 233690-51-2 {4-[1-(benzooxazol-2-yl-hydroxy-methyl)-3-phenyl-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyl}-carbamic acid tert-butyl ester 
• 233690-75-0 {4-[1-(benzothiazol-2-yl-hydroxy-methyl)-3-phenyl-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyl}-carbamic acid tert-butyl ester 
• 233690-59-0 2-[(2R)-4-Phenyl-2-amino-1-hydroxybutyl]-5,6-dimethylbenzoxazole 
• 233690-62-5 (R)-2-Amino-1-(5-chloro-benzooxazol-2-yl)-4-phenyl-butan-1-ol 
• 233690-50-1 (R)-2-Amino-1-benzooxazol-2-yl-4-phenyl-butan-1-ol 

Relevant academic research and scientific papers

MASP-2 INHIBITORS AND METHODS OF USE

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.

Iridium-catalyzed asymmetric allylic substitutions with bulky amines/oxidative double bond cleavage - Entry into the reetz synthesis of amino alcohols

Branched allylic amines were prepared by Ir-catalyzed enantioselective allylic aminations with the bulky N-nucleophiles HN(Boc)2 and HNBn2. The products were transformed into N-protected amino aldehydes, which were either reduced or coupled diastereoselectively with organometallic compounds to give vicinal amino alcohols. A formal synthesis of the neurokinin receptor antagonist (+)-L-733060 was carried out as an application. Ir-catalyzed enantioselective allylic aminations with bulky N-nucleophiles HN(Boc)2 and HNBn2 gave N-protected allylic amines, which were transformed into N-protected chiral amino aldehydes. These are useful chiral building blocks as previously demonstrated by Reetz et al. A formal synthesis of the neurokinin receptor antagonist (+)-L-733060 was carried out as an application.

Gold-catalyzed synthesis of enantioenriched furfurylamines from amino acids

Abstract A convenient gold-catalyzed asymmetric synthesis of polysubstituted furfurylamines starting from amino acids has been achieved. The cyclization proceeded under mild conditions and generally provided the furan or iodofuran derivatives in good to e

3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2

Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design allow

Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas a

Efflux pump inhibitors

Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.