233745-90-9Relevant academic research and scientific papers
COMPLEX AND STRUCTURALLY DIVERSE COMPOUNDS
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Paragraph 0270; 0271, (2015/12/20)
The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.
QUINOLINE DERIVATIVES AS ANTIBACTERIALS
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, (2008/06/13)
A method of treatment of bacterial infections in mammals, particularly in man, which method comprises the administration to a mammal in need of such treatment of an effective amount of a quinoline of formula (I) or a pharmaceutically acceptable derivative thereof wherein: n is 0, 1 or 2; A is NR, O, S(O)x or CRR and B is NR, O, S(O)x or CRR where x is 0, 1 or 2 novel quinolines for use in the method.
