233775-30-9

Usage

Uses

Used in Pharmaceutical Research:
6-Amino-1-Methyl-3,4-dihydroquinolin-2(1H)-one is used as a research compound for the development of new pharmaceuticals. Its unique structure and potential biological activities make it a valuable tool in the discovery and design of novel drugs.
Used in Organic Synthesis:
6-Amino-1-Methyl-3,4-dihydroquinolin-2(1H)-one is used as a building block in organic synthesis, allowing for the creation of various complex molecules with potential applications in different industries.
Used in Drug Discovery:
6-Amino-1-Methyl-3,4-dihydroquinolin-2(1H)-one is used as a starting material in drug discovery, where its unique properties can be leveraged to develop new therapeutic agents with improved efficacy and safety profiles.
Used in Medicinal Chemistry:
6-Amino-1-Methyl-3,4-dihydroquinolin-2(1H)-one is used as a compound of interest in medicinal chemistry, where its potential biological activities and pharmacological properties are studied to understand its therapeutic potential and guide the development of new drugs.

Upstream product

• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 22246-16-8 6-nitro-3,4-dihydro-1H-quinolin-2-one 
• 233775-29-6 1-methyl-6-nitro-3,4-dihydroquinolin-2(1H)-one 

Downstream Products

• 233775-31-0 (1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-carbamic acid benzyl ester 
• 1192709-12-8 6-(4-(4-fluorophenylamino)-5-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-1-methyl-3,4-dihydroquinolin-2(1H)-one 
• 1192709-13-9 6-(4-amino-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-1-methyl-3,4-dihydroquinolin-2(1H)-one 
• 1192709-14-0 6-(4-(benzylamino)-5-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-1-methyl-3,4-dihydroquinolin-2(1H)-one 
• 1192709-15-1 4-(benzylamino)-2-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, lI-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).

Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins

New phosphorous-containing lead structures against drought stress in crops interacting with RCAR/(PYR/PYL) receptor proteins were identified starting from in-depth SAR studies of related sulfonamide lead structures and protein docking studies. A converging 6-step synthesis via phosphinic chlorides and phosphono chloridates as key intermediates afforded envisaged tetrahydroquinolinyl phosphinamidates and phosphonamidates. Whilst tetrahydroquinolinyl phosphonamidates 13a,b exhibited low to moderate target affinities, the corresponding tetrahydroquinolinyl phosphinamidates 12a,b revealed confirmed strong affinities for RCAR/ (PYR/PYL) receptor proteins in Arabidopsis thaliana on the same level as essential plant hormone abscisic acid (ABA) combined with promising efficacy against drought stress in vivo (broad-acre crops wheat and canola).

BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF

The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.

N-aryl-2-oxazolidinone-5-carboxamides and their derivatives

The present invention provides antibacterial agents having the formulae I, II, and III described herein.

N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS

Compounds of formula B-C-A-CO-NH-R1, wherein A is structure i, ii or iii: formulae (I), (II), (III). C is optionally substituted aryl or heteroaryl, and B is a specified cyclic moiety, or C and B together are a heterobicyclic moiety, are useful as antibacterial agents.