23384-32-9Relevant academic research and scientific papers
Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents
Zhao, Anran,Li, Yaxin,Orahoske, Cody M.,Schnur, Brittny,Sabbagh, Abboud,Zhang, Wenjing,Li, Bibo,Su, Bin
, p. 1517 - 1528 (2019/03/05)
Previously synthesized tubulin inhibitors showed promising in vitro selectivity and activity against Human African Trypanosomiasis. Current aim is to improve the ligand efficiency and reduce overall hydrophobicity of the compounds, by lead optimization. V
