234077-49-7

Upstream product

• 39271-60-8 4-aminomethylbenzoyl-L-glutamic acid diethyl ester 
• 234077-47-5 2-pivaloylamino-6-methyl-5-<(dimethylamino)methyl>-4-oxo-7H-pyrrolo<2,3-d>pyrimidine 
• 172287-76-2 2-(pivaloylamino)-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo<2,3-d>pyrimidine 

Downstream Products

• 1053651-21-0 2-[4-({[2-(2,2-dimethyl-propionylamino)-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl]-amino}-methyl)-benzoylamino]-pentanedioic acid 

Relevant academic research and scientific papers

Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5- substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase

Compounds 2-5 were designed as potential antifolate nonpolyglutamatable inhibitors of thymidylate synthase (TS). These analogues are structurally related to 2-amino-4-oxo-5-substituted quinazolines and 2-amino-4-oxo-5- substituted pyrrolo[2,3-d]pyrimidine