234077-50-0Relevant academic research and scientific papers
Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5- substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase
Gangjee, Aleem,Mavandadi, Farahnaz,Kisliuk, Roy L.,Queener, Sherry F.
, p. 2272 - 2279 (2007/10/03)
Compounds 2-5 were designed as potential antifolate nonpolyglutamatable inhibitors of thymidylate synthase (TS). These analogues are structurally related to 2-amino-4-oxo-5-substituted quinazolines and 2-amino-4-oxo-5- substituted pyrrolo[2,3-d]pyrimidine
