234092-63-8Relevant academic research and scientific papers
Carbenylative amination with N-tosylhydrazones
Khanna, Avinash,Maung, Charles,Johnson, Kyle R.,Luong, Tom T.,Van Vranken, David L.
, p. 3233 - 3235 (2012/08/08)
A Pd-catalyzed reaction of vinyl iodides and N-tosylhydrazones that assembles η3-allyl ligands through carbene insertion is demonstrated. Intramolecular trapping with nitrogen nucleophiles generates good yields of cinnamyl and pentadienyl amines like those found in alkaloid natural products. Carbenylative amination was the key reaction to complete the synthesis of the alkaloid caulophyllumine B. Migratory insertion was biased to provide allylamines with optical purity up to 64% ee, but in a lower yield.
Intramolecular hydroamination of alkynes catalyzed by Pd(PPh 3)4/triphenylphosphine under neutral conditions
Bajracharya, Gan B.,Huo, Zhibao,Yamamoto, Yoshinori
, p. 4883 - 4886 (2007/10/03)
The intramolecular hydroamination of alkynes tethered with amino group 1 in the presence of catalytic amounts of Pd(PPh3)4 and PPh3 in benzene at 100°C proceeded smoothly without the use of any additional acid source to af
Hydroamination of alkynes catalyzed by palladium/benzoic acid
Lutete, Leopold Mpaka,Kadota, Isao,Shibuya, Akinori,Yamamoto, Yoshinori
, p. 347 - 357 (2007/10/03)
The reaction of internal alkynes (1) with amines (2) in the presence of catalytic amount of Pd(PPh3)4 and benzoic acid in dioxane at 100°C gave the allylic amines (3) in good to excellent yields. The intramolecular reaction of alkyne
