234106-08-2

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 3601-89-6 Hoffer's chlorosugar 
• 874-60-2 4-methyl-benzoyl chloride 
• 57236-72-3 C₂₃H₂₄O₇ 
• 1402406-34-1 1-acetyl-deoxyribose 
• 52162-55-7 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride 
• 4330-34-1 methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose 
• 51255-17-5 1-O-methyl-2-deoxy-D-ribofuranoside 
• 452-51-7 D-2-deoxyribose 

Downstream Products

• 234106-10-6 5-Methoxycarbonylmethyl-1-[(2R,4S,5R)-4-(4-methyl-benzoyloxy)-5-(4-methyl-benzoyloxymethyl)-tetrahydro-furan-2-yl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 1416717-97-9 1-[2′-deoxy-3′,5′-bis{O-(p-toluoyl)}-β-D-ribofuranosyl]-4-(phenanthren-9-yl)-1H-1,2,3-triazole 
• 1416718-02-9 1-(2′-deoxy-β-D-ribofuranosyl)-4-(3,5-dimethoxyphenyl)-1H-1,2,3-triazole 
• 1416717-98-0 1-[2′-deoxy-3′,5′-bis{O-(p-toluoyl)}-β-D-ribofuranosyl]-4-(3,5-dimethoxyphenyl)-1H-1,2,3-triazole 
• 1416717-99-1 1-[2′-deoxy-3′,5′-bis{O-(p-toluoyl)}-β-D-ribofuranosyl]-4-(4-nitrophenyl)-1H-1,2,3-triazole 
• 1416718-04-1 1-(2′-deoxy-β-D-ribofuranosyl)-4-(4-cyanophenyl)-1H-1,2,3-triazole 
• 1416718-00-7 1-[2′-deoxy-3′,5′-bis{O-(p-toluoyl)}-β-D-ribofuranosyl]-4-(4-cyanophenyl)-1H-1,2,3-triazole 
• 1416718-05-2 1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole 
• 1416718-06-3 1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(4-nitrophenyl)-1H-1,2,3-triazole 
• 1416718-03-0 1-(2′-deoxy-β-D-ribofuranosyl)-4-(4-nitrophenyl)-1H-1,2,3-triazole 
• 1416718-07-4 C₅₁H₅₄N₅O₆P 
• 1416718-08-5 C₄₃H₄₉N₆O₈P 
• 1529801-38-4 1-[2-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-(pyren-1-yl)-1H-1,2,3-triazol 
• 1402406-32-9 2-deoxy-1-(4-ethoxycarbonyl-5-ethylpropiolate-[1,2,3]triazol-1-yl)-3,5-di-O-(p-toluoyl)-α-D-ribofuranose 

Relevant academic research and scientific papers

Donor/acceptor chromophores-decorated triazolyl unnatural nucleosides: Synthesis, photophysical properties and study of interaction with BSA

Much effort has been put forth to develop unnatural, stable, hydrophobic base pairs with orthogonal recognition properties and study their effect on DNA duplex stabilisation. Our continuous efforts on the design of fluorescent unnatural biomolecular building blocks lead us to the synthesis of some triazolyl donor/acceptor unnatural nucleosides via an azide-alkyne 1,3-dipolar cycloaddition reaction as a key step, which we want to report herein. We have studied their photophysical properties and found interesting solvatochromic fluorescence for two of the nucleosides. Photophysical interactions among two donor-acceptor β-nucleosides as well as a pair of α/β-nucleosides have also been evaluated. Furthermore, we have exploited one of the fluorescent nucleosides in studying its interaction with BSA with the help of UV-visible and steady state fluorescence techniques. Our design concept is based on the hypothesis that a pair of such donor/acceptor nucleosides might be involved in π-stacking as well as in photophysical interactions, leading to stabilization of the DNA duplex if such nucleosides can be incorporated into short oligonucleotide sequences. Therefore, the designed bases may find application in biophysical studies in the context of DNA.

ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPUETIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME

Acadesine derivatives as a drug, as well as the derivatives for the treatment of cancer and in particular for the treatment of chronic myeloid leukemia are described. Also, product containing the derivatives and at least one second active ingredient as a

Triazolyl donor/acceptor chromophore decorated unnatural nucleosides and oligonucleotides with duplex stability comparable to that of a natural adenine/thymine pair

We report the design and synthesis of triazolyl donor/acceptor unnatural nucleosides via click chemistry and studies on the duplex stabilization of DNA containing two such new nucleosides. The observed duplex stabilization among the self-pair/heteropair has been found to be comparable to that of a natural A/T pair. Our observations on the comparable duplex stabilization has been explained on the basis of possible π-π stacking and/or charge transfer interactions between the pairing partners. The evidence of ground-state charge transfer complexation came from the UV-vis spectra and the static quenching of fluorescence in a heteropair. We have also exploited one of our unnatural DNAs in stabilizing abasic DNA.

Unnatural triazolyl nucleoside stabilizes an abasic site containing DNA duplex equally as the stabilization of a natural A-T pair

A better than reported abasic duplex stabilization was achieved with the novel triazolylphenanthrene nucleoside TPhenBDo. The large surface area, polarizability and strong stacking propensity of triazolylphenanthrene play a major rol

Simple and stereoselective preparation of an 4-(aminomethyl)-1,2,3- triazolyl nucleoside phosphoramidite

A simple and stereoselective synthesis of a protected 4-(aminomethyl)-1-(2- deoxy-β-D-ribofuranosyl)-1,2,3-triazole cyanoethyl phosphoramidite was developed for the modification of synthetic oligonucleotides. The configuration of the 1,2,3-triazolyl moiet

An efficient stereospecific method for the synthesis of 8-aza-3-deazaguanine nucleosides from glycosyl azides

8-aza-3-deazaguanine nucleosides 8 were prepared from glycosyl azides 1 via a stereospecific Dimroth reaction with dimethyl 3-oxoglutarate, followed by selective manipulation of the 1,2,3-triazole C-4 and 5 substituents. Of the two methods evaluated for t