234109-17-2Relevant academic research and scientific papers
Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination
Ichikawa, Saki,Buchwald, Stephen L.
supporting information, p. 8736 - 8739 (2019/11/03)
Asymmetric synthesis of γ-amino alcohols from unprotected allylic alcohols by a copper-catalyzed hydroamination strategy has been developed. Using easily accessible starting materials, a range of chiral 1,3-amino alcohols were prepared with excellent regio- and enantioselectivity. Further, this protocol provided an efficient one-step method for the enantioselective synthesis of γ-amino alcohols in an intermolecular manner.
HETEROCYCLIC AMIDES AS KINASE INHIBITORS
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Page/Page column 80; 81, (2016/12/07)
Disclosed are compounds having the formula: (I) wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.
Nonpeptide αvβ3 antagonists: Identification of potent, chain-shortened 7-oxo RGD mimetics
Zartman, Amy E.,Duong, Le T.,Fernandez-Metzler, Carmen,Hartman, George D.,Leu, Chih-Tai,Prueksaritanont, Thomayant,Rodan, Gideon A.,Rodan, Sevgi B.,Duggan, Mark E.,Meissner, Robert S.
, p. 1647 - 1650 (2007/10/03)
Potent, novel 7-oxo αvβ3 antagonists have been prepared. These antagonists offer decreased plasma protein binding and excellent pharmacokinetic profiles.
Substituted oxoazaheterocyclyl compounds
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Page/Page column 74, (2008/06/13)
This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..
