23432-43-1

Basic information

• Product Name: 6-CHLORO-4-HYDROXYQUINOLINE
• Synonyms: 4-HYDROXY-6-CHLOROQUINOLINE;6-CHLORO-4-HYDROXYQUINOLINE;6-CHLOROQUINOLIN-4(1H)-ONE;6-CHLOROQUINOLIN-4-OL;6-CHLORO-4-QUINOLINOL
• CAS NO: 23432-43-1
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.6
• EINECS: -0
• Mol File: 23432-43-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 269°C(lit.)
• Boiling Point: 306.9 ºC at 760 mmHg
• Flash Point: 139.4 ºC
• Appearance: /
• Density: 1.339 g/cm³
• Vapor Pressure: 0.000748mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.89±0.40(Predicted)
• CAS DataBase Reference: 6-CHLORO-4-HYDROXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-4-HYDROXYQUINOLINE(23432-43-1)
• EPA Substance Registry System: 6-CHLORO-4-HYDROXYQUINOLINE(23432-43-1)

Safety Data

• Hazard Codes: E,Xn
• Statements: 22
• Hazardous Substances Data: 23432-43-1(Hazardous Substances Data)

Usage

Chemical Properties

off White powder

InChI:InChI=1/C9H6ClNO/c10-6-1-2-8-7(5-6)9(12)3-4-11-8/h1-5H,(H,11,12)

Upstream product

• 21617-20-9 6-chloro-2,3-dihydro-4(1H)-quinolone 
• 2032-24-8 N,N'-di(p-chlorophenyl)formamidine 
• 106-47-8 4-chloro-aniline 
• 21617-19-6 3-(4-chlorophenylamino)propionic acid 
• 70271-77-1 6-chloro-4-hydroxyquinoline-3-carboxylic acid ethyl ester 
• 35973-14-9 6-chloro-4-hydroxy-3-quinoline carboxylic acid 
• 197513-34-1 N-(4-chloro-phenyl)-N-(toluene-4-sulfonyl)-β-alanine 
• 76227-93-5 ethyl 3-((4-chlorophenyl)amino)propanoate 
• 19056-79-2 diethyl 4-chloroanilinomethylenemalonate 
• 25063-46-1 5-(((4-chlorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 4203-18-3 4,6-dichloroquinoline 
• 66735-24-8 4-Amino-6-chlor-2-methylchinolin 
• 25771-83-9 3,6-dichloro-quinolin-4-ol 
• 860230-86-0 3-bromo-6-chloro-quinolin-4-ol 
• 25771-76-0 3,4,6-Trichlor-chinolin 
• 1621083-01-9 N-{4-chloro-2-[1-(phenylsulfonyl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide 
• 1621082-97-0 N-(4-chloro-2-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-3-yl}phenyl)-4-methylbenzenesulfonamide 
• 1082748-39-7 C₉H₈ClN₃ 

Relevant articles and documents

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

Senexins are potent and selective quinazoline inhibitors of CDK8/19 Mediator kinases. To improve their potency and metabolic stability, quinoline-based derivatives were designed through a structure-guided strategy based on the simulated drug–target dockin

Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform ix inhibitors

A new series of quinoline-based benzenesulfonamides (QBS) were developed as potential carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4-anilinoquinoline scaffold where the primary sulphonamide functionality was grafted at C4 of t

Oxidation method of 4-oxo-2,3-dihydroquinoline compound

The invention discloses an oxidation method of a 4-oxo-2,3-dihydroquinoline compound. The method comprises the following steps: taking the 4-oxo-2,3-dihydroquinoline compound as a raw material; addingan organic solvent, an acidifying agent and an oxidizing agent; performing oxidation reaction at 50-85 DEG C; and after the reaction is finished, performing post-treatment on the reaction liquid to obtain a 4-hydroxyquinoline compound. Various raw materials used by the preparation method disclosed by the invention are simple and easy to obtain, are industrial products and have wide sources and low price; the preparation method is simple, easy to operate and high in product yield; compared with the traditional oxidation method of the 4-oxo-2,3-dihydroquinoline compound, the method disclosed bythe invention has the advantages of being more efficient and simpler in post-treatment; and the method is especially important for the industrialization of the product.