23441-00-1Relevant academic research and scientific papers
Synthesis of a variety of 2-alkyl-2-azabicyclo[31.1]heptane-1-carbonitriles via a dynamic addition-intramolecular substitution sequence
De Blieck, Ann,Stevens, Christian V.
supporting information; experimental part, p. 1748 - 1752 (2011/09/20)
An improved two-step synthetic approach towards 3-(2-chloroethyl) cyclobutanone is described and used in the synthesis of a class of 2-alkyl-2-azabicyclo[3.1.1]heptane-1-carbonitriles. The key step consists of a reversible addition of hydrogen cyanide ont
