234452-71-2

Upstream product

• 3070-71-1 methyl 2-benzylacrylate 
• 142178-56-1 Methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate 
• 115961-49-4 [2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid 
• 207286-71-3 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid 

Downstream Products

• 1019330-86-9 C₂₉H₄₁N₂O₇P 

Relevant academic research and scientific papers

Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2

Angiotensin-Converting enzyme 2 (ACE2), a recently identified human homologue of angiotensin-converting enzyme, is a zinc metallocarboxypeptidase which may play a unique role in cardiovascular and renal function. Here we report the discovery of potent and

Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor

A series of phosphinic compounds mimicking the transition state of substrates hydrolysed by aminopeptidase N (EC 3.4.11.2) were synthesized. These new compounds have potent inhibitory activities with Ki values in the nanomolar range. These derivatives behave as the most potent APN inhibitors designed to date.