23450-37-5Relevant academic research and scientific papers
Synthesis of 6-naphthoxy and 6-(α-cyanobenzyl)-3, 4-dihydropyrimidin-4-(3 H)-ones as potent HIV-1 inhibitors
Chen, Guo-Shen,Du, Fen,Zhao, Tian-Sheng,Xiong, Yuan-Zhen
, p. 255 - 260 (2018/09/14)
A series of novel dihydroalkoxybenzyloxopyrimidines (S-DABOs) derivatives were synthesized as potent inhibitors of human immunodeficiency virus type-1 (HIV-1) through one-pot procedure. The chemical modification, which included the replacement of the 6-ar
Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Wu, Hai-Qiu,Pannecouque, Christophe,Yan, Zi-Hong,Chen, Wen-Xue,He, Qiu-Qin,Chen, Fen-Er,Balzarini, Jan,Daelemans, Dirk,De Clercq, Erik
, p. 468 - 473 (2014/04/17)
A series of conformationally restricted dihydro-alkylthio-benzyl- oxopyrimidine (S-DABO) hybrids, which combined the structural features of C6-α-methylbenzyl-thio-DABOs (α-methyl-S-DABOs) and C6-α-cyanobenzyl-thio-DABOs (CN-S-DABOs), has been synthesized and biologically evaluated for their anti-HIV activity against wild-type HIV-1 strain IIIB, double RT mutant (K103N + Y181C) strain RES056 and HIV-2 strain ROD in MT-4 cell cultures. Most of these compounds exhibited inhibitory activity (wild-type) within the range of EC50 values from micromolar to nanomolar. Among them, compound 1s displayed the highest anti-HIV-1 activity with an EC50 value of 91 nM and a selectivity index (SI) of 548, which was more potent than zalcitabine and comparable to nevirapine and delavirdine in the same assay. The HIV-1 reverse transcriptase inhibitory (RT) assay confirmed that these conformationally restricted S-DABO hybrids targeted HIV-1 RT. The preliminary structure-activity relationship (SAR) and molecular docking analysis of this new series of conformationally constrained CN-S-DABO hybrids were also investigated.
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies
Wu, Hai-Qiu,Yan, Zi-Hong,Chen, Wen-Xue,He, Qiu-Qin,Chen, Fen-Er,De Clercq, Erik,Balzarini, Jan,Daelemans, Dirk,Pannecouque, Christophe
, p. 6477 - 6483 (2013/10/22)
A series of C6-rigid S-DABO analogs characterized by a substituted benzoyl group at C6 position of the pyrimidine ring has been synthesized and biological evaluation as NNRTIs against wild-type HIV-1 strain IIIB, double RT mutant (K103N + Y181C) strain RES056 as well as HIV-2 strain ROD in MT-4 cell cultures. Most of the compounds exhibited moderate antiviral activities. Among them, compound 7q displayed the highest anti-HIV-1 activity with an EC50 value of 0.26 μM and a selectivity index (SI) of 541. The preliminary structure-activity relationship (SAR) of these new S-DABOs was investigated, the target RT was confirmed and docking study was performed.
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6- (arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
Ji, Lei,Chen, Fen-Er,De Clercq, Erik,Balzarini, Jan,Pannecouque, Christophe
, p. 1778 - 1786 (2008/02/01)
A series of novel S-DABO analogues (S-DABOs, 1) were synthesized and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). Key structural modifications included replacement of the 6-arylmethyl group by a 6-arylcarbonyl or 6-(α-cyanoarylmethyl) group. Most of the compounds showed only micromolar potency against HIV-1 in MT-4 cells in vitro, though two of them (3e and 3g) were unusually potent (IC50 = 0.09 and 0.002 μM, respectively) and selective (SI = 1500 and 4600, respectively). Structure-activity relationships among the newly synthesized S-DABOs are discussed.
