2346-00-1

Basic information

• Product Name: 2-Methyl-2-thiazoline
• Synonyms: 2-methyl-2-thiazolidine;2-methyl-2-thiazolin;2-Methyl-4,5-dihydro-1,3-thiazole;2-Methyl-delta2-thiazoline;2-Methyldihydrothiazole;2-Thiazoline, 2-methyl-;4,5-dihydro-2-methyl-thiazol;4,5-dihydro-2-methylthiazole
• CAS NO: 2346-00-1
• Molecular Formula: C₄H₇NS
• Molecular Weight: 101.17
• EINECS: 219-071-6
• Product Categories: Heterocyclic Compounds;thiazole Flavor;Alphabetical Listings;Flavors and Fragrances;M-N;Building Blocks;Heterocyclic Building Blocks;Thiazolines/Thiazolidines;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 2346-00-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: -101.0 °C(lit.)
• Boiling Point: 144.0-145.0 °C(lit.)
• Flash Point: 99 °F
• Appearance: colorless/liquid
• Density: 1.067 g/mL at 25 °C(lit.)
• Vapor Pressure: 6.25mmHg at 25°C
• Refractive Index: n20/D 1.520(lit.)
• Storage Temp.: 2-8°C
• PKA: 5.26±0.10(Predicted)
• BRN: 104274
• CAS DataBase Reference: 2-Methyl-2-thiazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-thiazoline(2346-00-1)
• EPA Substance Registry System: 2-Methyl-2-thiazoline(2346-00-1)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 2
• RTECS: XJ4261470
• F: 8-10-23
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 2346-00-1(Hazardous Substances Data)

Usage

Chemical Properties

colorless to orange-yellow liquid

Uses

Meyers reagent for aldehyde synthesis.

InChI:InChI=1/C4H7NS/c1-4-5-2-3-6-4/h2-3H2,1H3

Upstream product

• 141-43-5 ethanolamine 
• 62-55-5 thioacetamide 
• 64-19-7 acetic acid 
• 74-85-1 ethene 
• 75-05-8 acetonitrile 
• 75-36-5 acetyl chloride 
• 7647-01-0 hydrogenchloride 
• 1190-73-4 2-(acetylamino)ethanethiol 
• 108-24-7 acetic anhydride 
• 24050-16-6 2-methylthiazolidine 
• 75-07-0 acetaldehyde 
• 60-23-1 Cysteamine 
• 927-80-0 1-ethoxyacetylene 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 97855-56-6 (4,5-dihydro-thiazol-2-yl)-acetone 
• 27565-37-3 (E)-2-[2-phenylethenyl]-4,5-dihydro-1,3-thiazole 
• 27565-38-4 2-[trans-2-(4,5-dihydro-thiazol-2-yl)-vinyl]-phenol 
• 54654-71-6 2-methyl-3-ethyl-4,5-dihydrothiazolium iodide 
• 105209-47-0 8a-methyl-6,6,8,8-tetraphenyl-tetrahydro-thiazolo[3,2-a]pyridine-5,7-dione 
• 26934-29-2 2,3-dimethylthiazolinium iodide 
• 3581-87-1 2-methylthiazole 
• 40052-00-4 N-benzoyl-thioglycine S-{2-[1-(5-oxo-3-phenyl-2H-isoxazol-4-yl)-ethylideneamino]-ethyl} ester 
• 1025-89-4 5‐methyl‐1,3‐diphenyl‐1H‐1,2,4‐triazole 
• 115591-24-7 5-methyl-1-(4-nitrophenyl)-3-phenyl-1H-1,2,4-triazole 
• 1202924-85-3 7-phenyl-2,3-dihydrothiazolo[3,2-c]pyrimidin-5-thione 
• 1202924-76-2 7-phenyl-2,3-dihydrothiazolo[3,2-c]pyrimidin-5-one 

Relevant articles and documents

Reactions of 2-methylthiazolines and N-methyl cyclic ketene-N,S-acetals with acid chlorides

Carbon-carbon bond formation occurs under mild conditions when 2-methylthiazolines react with acid chlorides to form N-acyl-β-keto cyclic ketene-N,S-acetals. N-Methyl cyclic ketene-N,S-acetals, generated from 2-methyl-thiazolines, can react further with acid chlorides to form N-methyl-β-keto cyclic ketene-N,S-acetals.

Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging

Provided are, among other things, compounds of formula I or IA, . Also provided are methods of treatment with such compounds.

Novel synthesis of 2-thiazolines

The synthesis of a series of 2-thiazolines was carried out under mild conditions from the corresponding thiazolidines, by a Ru-catalyzed/TBHP oxidation reaction conditions. The reaction was chemoselective towards the amine-imine oxidation and was also regioselective, affording the unsaturation at the 2-position of the heterocycle, even with thiazolidine substrates bearing ester groups at the 4-position. (C) 2000 Elsevier Science Ltd.