23474-83-1

Basic information

• Product Name: 2-bromo-1-(3,4-dimethoxyphenyl)butan-1-one
• Synonyms: 2-bromo-1-(3,4-dimethoxyphenyl)butan-1-one
• CAS NO: 23474-83-1
• Molecular Weight: 287.153
• Mol File: 23474-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-1-(3,4-dimethoxyphenyl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(3,4-dimethoxyphenyl)butan-1-one(23474-83-1)
• EPA Substance Registry System: 2-bromo-1-(3,4-dimethoxyphenyl)butan-1-one(23474-83-1)

Safety Data

• Hazardous Substances Data: 23474-83-1(Hazardous Substances Data)

Upstream product

• 54419-21-5 1-(3,4-dimethoxyphenyl)butan-1-one 

Relevant articles and documents

Unexpected Role of p-Toluenesulfonylmethyl Isocyanide as a Sulfonylating Agent in Reactions with α-Bromocarbonyl Compounds

The reactions of p-toluenesulfonylmethyl isocyanide (TosMIC) with α-bromocarbonyl compounds leading efficiently to α-sulfonated ketones, esters, and amides were reported, in which an explicit new role of TosMIC as the sulfonylating agent was uncovered for the first time. Mechanistic study by control experiments and DFT calculations suggested that the reaction is initiated by Cu(OTf)2-catalyzed hydration of TosMIC to form a formamide intermediate, which undergoes facile C-S bond cleavage under the mediation of a Cs2CO3 additive.