23474-98-8

Basic information

• Product Name: 2-AMINO-5-CHLOROTHIOPHENOL
• Synonyms: 2-AMINO-5-CHLOROTHIOPHENOL;BUTTPARK 35\02-18;2-AMINO-5-CHLOROBENZENETHIOL;2-aMino-5-chlorobenzene-1-thiol;Benzenethiol,2-aMino-5-chloro-;2-Amino-5-chlorothiophenol 98%;4-Chloro-2-thioaniline, 4-Chloro-2-mercaptoaniline;2-Amino-5-chlorothiophenol98%
• CAS NO: 23474-98-8
• Molecular Formula: C₆H₆ClNS
• Molecular Weight: 159.64
• Mol File: 23474-98-8.mol
• Article Data: 26

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 278 °C at 760 mmHg
• Flash Point: 121.9 °C
• Appearance: /
• Density: 1.372 g/cm³
• PKA: 7.77±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-CHLOROTHIOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CHLOROTHIOPHENOL(23474-98-8)
• EPA Substance Registry System: 2-AMINO-5-CHLOROTHIOPHENOL(23474-98-8)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 23474-98-8(Hazardous Substances Data)

Usage

Uses

2-?Amino-?5-?chlorobenzenethiol is a reagent used in the preparation of indane-based 1,5-benzothiazapines containing antimicrobial activity.

Upstream product

• 95-24-9 6-chloro-2-aminobenzothiazole 
• 35576-53-5 6-Chloro-1,2,3-benzodithiazol-1-ium chloride 
• 4146-24-1 6-chloro-2-methylbenzo[d]thiazole 
• 59280-70-5 4'-chloro-2'-fluoroacetanilide 
• 3696-23-9 N-(4-chlorophenyl)thiourea 
• 1367199-79-8 BrH*C₇H₅ClN₂S 
• 106-47-8 4-chloro-aniline 
• 57946-56-2 2-fluoro-4-chloroaniline 
• 31183-89-8 2-[(2-amino-5-chlorophenyl)dithio]-4-chlorophenylamine 
• 2942-10-1 6-chloro-1,3-benzothiazole 

Downstream Products

• 418783-16-1 (2-amino-5-chloro-phenylsulfanyl)-acetic acid 
• 108650-65-3 2-tert-butyl-6-chloro-2-methyl-2,3-dihydro-benzothiazole 
• 54531-34-9 1-(6-chloro-1H-benzothiazol-2-yl)ethanol 
• 60598-36-9 6-anilino-9-chloro-benzo[a]phenothiazin-5-one 
• 106629-28-1 {2-[4-(6-chloro-benzothiazol-2-yl)-phenoxy]-ethyl}-triethyl-ammonium; iodide 
• 31183-89-8 2-[(2-amino-5-chlorophenyl)dithio]-4-chlorophenylamine 
• 14468-66-7 6-chloro-2-trichloromethyl-benzothiazole 
• 31639-73-3 3-chloro-8,9-dinitro-12H-benzo[5,6][1,4]thiazino[2,3-b]quinoxaline 
• 99839-04-0 6-chloro-2,2-dimethyl-2,3-dihydro-benzothiazole 
• 20988-73-2 10-chloro-2,3-dimethoxy-7H-benzo[5,6][1,4]thiazino[3,2-c]cinnoline 
• 110766-90-0 8-Chloro-2-methyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 14517-19-2 (7-Chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-acetic acid 
• 86328-27-0 2-(6-Chloro-benzothiazol-2-ylamino)-5,6-dimethyl-pyrimidin-4-ol 
• 51618-29-2 6-chloro-2-mercaptobenzothiazole 

Relevant articles and documents

Synthesis and insecticidal evaluation of novel sulfide-containing amide derivatives as potential ryanodine receptor modulators

With the aim of discovering new bioactive pesticides for crop protection, a series of novel sulfide-containing amide derivatives A were efficiently synthesized via a strategy of modifying the “amide” structure of anthranilic diamide insecticides. The single-crystal structures of A2-3 and A4-5 were firstly reported. The bioassay results showed that most of the synthesized compounds display moderate to high insecticidal activities. Particularly, some sulfone-containing compounds, e.g., A2-3, A3-3 and A6-3, not only possessed favorable lethality rate (50%–100%) against P. xylostella at a concentration of 0.1 mg/L, but also held good activities towards a variety of agricultural pests such as M. separata, C. pipiens pallen, H. armigera and O. nubilalis; the larvicidal activities of A4-1 and A6-1 towards P. xylostella were close to that of chlorantraniliprole at 0.01 mg/L. The calcium imaging experiments revealed that the representative compounds A2-3 and A6-3 are potential ryanodine receptor (RyR) modulators. The structure–activity relationships were discussed in detail. These results provide useful information for further design and development of novel insecticides.

Facile syntheses of 3-trifluoromethylthio substituted thioflavones and benzothiophenes via the radical cyclization

3-CF3S substituted thioflavones and benzothiophenes were achieved via the reactions of AgSCF3 with methylthiolated alkynones and alkynylthioanisoles, respectively, promoted by persulfate. This protocol possesses good functional group tolerance and high yields. Mechanistic studies suggested that a classic two-step radical process was involved, which includes addition of CF3S radical to triple bond and cyclization with SMe moiety.

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.