23478-25-3

Usage

Uses

Used in Sunscreen Products:
N-(3-Hydroxyphenyl)cinnamamide is used as a sunscreen ingredient for its ability to absorb ultraviolet (UV) radiation, providing protection against harmful UV rays and reducing the risk of skin damage and premature aging.
Used in Skincare and Cosmetic Products:
N-(3-Hydroxyphenyl)cinnamamide is used as an active ingredient in skincare and cosmetic products due to its antioxidant and anti-inflammatory properties. It helps to protect the skin from oxidative stress and inflammation, promoting a healthy and youthful appearance.
Used in Pharmaceutical Industry:
N-(3-Hydroxyphenyl)cinnamamide is used as a potential therapeutic agent in the treatment of neurological disorders and various diseases. Its diverse range of biological activities makes it a promising candidate for the development of new drugs and therapies.
Used in Research and Development:
N-(3-Hydroxyphenyl)cinnamamide is used as a target for further research and development in various fields, including pharmaceuticals, cosmetics, and sunscreen products. Its unique properties and potential applications make it an interesting compound for scientists and researchers to explore and innovate.

Upstream product

• 621-82-9 Cinnamic acid 
• 591-27-5 m-Hydroxyaniline 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 102-92-1 Cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 102-92-1 cinnamoyl chloride 

Relevant academic research and scientific papers

Structure–activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid

In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d–6g, 10d–12g, 16d–18g and 22d–24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. The results revealed that the alteration of aminoalkyl types and substituted positions markedly influences the effects in inhibiting AChE. Almost of all cinnamic acid derivatives had the most potent inhibitory activity than that of other acid derivatives with the same aminoalkyl side chain. Unsaturated bond and benzene ring in cinnamic acid scaffold seems important for the inhibitory activity against AChE. Among them, compound 6g revealed the most potent AChE inhibitory activity (IC50 value: 3.64 μmol/L) and highest selectivity over BChE (ratio: 28.6). Enzyme kinetic study showed that it present a mixed-type inhibition against AChE. The molecular docking study suggested that it can bind with the catalytic site and peripheral site of AChE.

PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE

Processes for preparation of Brexpiprazole, intermediates used during preparation, and polymorphs of Brexpiprazole are provided.

Ligand- and Additive-Controlled Pd-Catalyzed Aminocarbonylation of Alkynes with Aminophenols: Highly Chemo- and Regioselective Synthesis of α,β-Unsaturated Amides

This work describes the chemo- and regioselective direct aminocarbonylation of alkynes and aminophenols to form hydroxy-substituted α,β-unsaturated amides in good to excellent yields. The latter are valuable compounds in pharmaceuticals and natural products. By a simple choice of different ligands and additives, branched or linear isomers could be selectively formed in excellent regioselectivity. Using a combination of boronic acid and 5-chlorosalicylic acid ( BCSA ) as the additives, linear amides were obtained in high yields and selectivities using 1,2-bis(di-tert-butylphosphinomethyl)benzene (DTBPMB) as the ligand. On the other hand, branched amides could be approached by introducing 1,3-bis(diphenylphosphino)propane as the ligand and p-TsOH·H2O as the additive. In addition to the hydroxyl group, other functional substituents, such as carboxyl and vinyl groups, could also be tolerated using this method. As an application of this strategy, the natural product avenanthramide A could be synthesized directly in 84% yield and in 99% regioselectivity via the carbonylation of 2-amino-5-hydroxybenzoic acid and 4-ethynylphenol. Further studies show that the ligands and the additives are keys to good yields and selectivities.

Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors

Four series of acid amides were synthesized, and through measurement using a fluorogenic substrate assay with human recombinant MMP-1, MMP-2 and MMP-9, compound 3f showed considerable inhibitory activities against MMP-2, MMP-9 and the best selectivity over MMP-1. Preliminary structure-activity relationship analysis indicated that caffeic acid amides with electron-donating groups at para-position of amino phenyl group showed better inhibitory activities and selectivity than those with electron-withdrawing groups, and the presence of adjacent dihydroxy in the caffeoyl group was very important for the MMP-2 and MMP-9 inhibitory activities.

Meta-bifunctional benzenes and herbicidal compositions

Meta-bifunctional of the general formula EQU1 wherein A is selected from the groups EQU2 These compounds possess herbicidal activity.