23506-20-9

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 1080-06-4 L-Tyr-OMe 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 

Downstream Products

• 72210-21-0 N-t-butyloxycarbonyl-L-tyrosyl-L-leucine benzyl ester 
• 90544-96-0 (S)-2-({(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester 
• 71591-33-8 Boc-Tyr-azide 
• 579490-94-1 Boc-Tyr-Pro-Phe-NH-phenethyl 
• 714970-51-1 [2-[2-(1-tert-butylcarbamoyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 714970-35-1 ((S)-1-(4-Hydroxy-benzyl)-2-oxo-2-{(S)-2-[(S)-2-phenyl-1-(pyridin-3-ylcarbamoyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester 
• 714970-37-3 ((S)-1-(4-Hydroxy-benzyl)-2-oxo-2-{(S)-2-[(S)-2-phenyl-1-(pyridin-2-ylcarbamoyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester 
• 714970-31-7 {(S)-1-(4-Hydroxy-benzyl)-2-oxo-2-[(S)-2-((S)-2-phenyl-1-phenylcarbamoyl-ethylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester 
• 714970-33-9 ((S)-1-(4-Hydroxy-benzyl)-2-oxo-2-{(S)-2-[(S)-2-phenyl-1-(pyridin-4-ylcarbamoyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester 
• 714970-53-3 [(S)-2-[(S)-2-((S)-1-Cyclohexylcarbamoyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 714970-49-7 ((S)-1-(4-Hydroxy-benzyl)-2-{(S)-2-[(S)-1-(isoquinolin-5-ylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester 
• 714970-43-1 ((S)-1-(4-Hydroxy-benzyl)-2-oxo-2-{(S)-2-[(S)-2-phenyl-1-(quinolin-5-ylcarbamoyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester 
• 714970-39-5 ((S)-1-(4-Hydroxy-benzyl)-2-{(S)-2-[(S)-1-(naphthalen-1-ylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester 
• 714970-47-5 ((S)-1-(4-Hydroxy-benzyl)-2-oxo-2-{(S)-2-[(S)-2-phenyl-1-(quinolin-8-ylcarbamoyl)-ethylcarbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Amino Acid Functionalized Organotin Trichlorides and Their Tin Sulfide Clusters

We present a new synthesis of functionalized tin sulfide clusters via organotin trichlorides with boc-protected amino acids (RAAcSnCl3). In this work we used non-polar (alanine, valine, leucine, phenylalanine and methionine), polar/neutral (serine and tyrosine) and basic (histidine) amino acids. We obtained single crystals from a Boc-protected valine derivative of the originally used organotin trichloride R1SnCl3 [R1 = CMe2CH2C(O)Me] and determined its structure by means of X-ray diffraction. A subsequent reaction with sulfide sources led to a variety of respective cluster structures. By using either (Me3Si)2S or Na2S, the reaction product turns out to be the defect-heterocubane cluster [(RAAcSn)3S4Cl] or the “doppeldecker”-type cluster [(RAAcSn)4S6], respectively, according to 119Sn NMR spectroscopy.

2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors

Human coxsackievirus B3 (CVB3) 3C protease plays an essential role in the viral replication of CVB3, which is a non-enveloped and positive single-stranded RNA virus belonging to Picornaviridae family, causing acute viral myocarditis mainly in children. During optimization based on SAR studies of benserazide (3), which was reported as a novel anti-CVB3 3Cpro agent from a screening of compound libraries, the 2,3,4-trihydroxybenzyl moiety of 3 was identified as a key pharmacophore for inhibitory activity against CVB3 3Cpro. Further optimization was performed by the introduction of various aryl-alkyl substituted hydrazide moieties instead of the serine moiety of 3. Among the optimized compounds, 11Q, a 4-hydroxyphenylpentanehydrazide derivative, showed the most potent inhibitory activity (IC50 Combining double low line 0.07 μM). Enzyme kinetics studies indicated that 11Q exhibited a mixed inhibitory mechanism of action. The antiviral activity against CVB3 was confirmed using the further derived analogue (14b) with more cell permeable valeryl ester group at the 2,3,4-trihydroxy moiety.