235088-69-4

Basic information

• Product Name: 3,4,5-Trifluorobenzylamine
• Synonyms: 3,4,5-TRIFLUOROBENZYLAMINE;RARECHEM AL BW 0701;Benzenemethanamine, 3,4,5-trifluoro- (9CI);3,4,5-Trifluorobenzylamine,97%;3,4,5-Trifluorobenzylamine 98%;3,4,5-Trifluorobenzylamine98%;(3,4,5-Trifluorophenyl)methanamine;Trifluorobenzylamine 345-
• CAS NO: 235088-69-4
• Molecular Formula: C₇H₆F₃N
• Molecular Weight: 161.12
• Product Categories: HALIDE;Amine;Fluorine series
• Mol File: 235088-69-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 176.3 °C at 760 mmHg
• Flash Point: 69.4 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 1.1mmHg at 25°C
• Refractive Index: 1.4736
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.49±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3,4,5-Trifluorobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-Trifluorobenzylamine(235088-69-4)
• EPA Substance Registry System: 3,4,5-Trifluorobenzylamine(235088-69-4)

Safety Data

• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 235088-69-4(Hazardous Substances Data)

Usage

General Description

3,4,5-Trifluorobenzylamine is a chemical compound with the molecular formula C7H6F3N. It is a derivative of benzylamine with three fluorine atoms attached to the benzene ring. 3,4,5-Trifluorobenzylamine is commonly used in scientific research as a building block for the synthesis of various pharmaceuticals and agrochemicals. It can also be utilized in the production of polymers, dyes, and other industrial chemicals. 3,4,5-Trifluorobenzylamine is a highly reactive compound and should be handled with caution in a controlled laboratory environment.

InChI:InChI=1/C7H6F3N/c8-5-1-4(3-11)2-6(9)7(5)10/h1-2H,3,11H2

Upstream product

• 134227-45-5 3,4,5-trifluorobenzonitrile 

Downstream Products

• 1624256-30-9 8-(3,4,5-trifluorobenzyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrazino[2,1-f]purine-2,4(1H,3H)-dione 
• 1423073-52-2 C₁₄H₇F₆N 
• 1381859-59-1 (Z)-4-chloro-N-(((3,4,5-trifluorobenzyl)amino)((3-(trifluoromethyl)-1H-pyrazol-5-yl)amino)methylene)benzamide 
• 1001413-59-7 C₁₅H₁₂F₃NO₃ 

Relevant articles and documents

Cobalt-based nanoparticles prepared from MOF-carbon templates as efficient hydrogenation catalysts

The development of efficient and selective nanostructured catalysts for industrially relevant hydrogenation reactions continues to be an actual goal of chemical research. In particular, the hydrogenation of nitriles and nitroarenes is of importance for the production of primary amines, which constitute essential feedstocks and key intermediates for advanced chemicals, life science molecules and materials. Herein, we report the preparation of graphene shell encapsulated Co3O4- and Co-nanoparticles supported on carbon by the template synthesis of cobalt-terephthalic acid MOF on carbon and subsequent pyrolysis. The resulting nanoparticles create stable and reusable catalysts for selective hydrogenation of functionalized and structurally diverse aromatic, heterocyclic and aliphatic nitriles, and as well as nitro compounds to primary amines (>65 examples). The synthetic and practical utility of this novel non-noble metal-based hydrogenation protocol is demonstrated by upscaling several reactions to multigram-scale and recycling of the catalyst.