235094-27-6

Basic information

• Product Name: (2S,3S,3aS,4aR,6R,8aS)-2,6,9,9-Tetramethyl-3-phenyl-octahydro-benzo[e]pyrrolo[2,1-b][1,3]oxazin-1-one
• Synonyms: (2S,3S,3aS,4aR,6R,8aS)-2,6,9,9-Tetramethyl-3-phenyl-octahydro-benzo[e]pyrrolo[2,1-b][1,3]oxazin-1-one
• CAS NO: 235094-27-6
• Molecular Weight: 327.467
• Mol File: 235094-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S,3aS,4aR,6R,8aS)-2,6,9,9-Tetramethyl-3-phenyl-octahydro-benzo[e]pyrrolo[2,1-b][1,3]oxazin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S,3aS,4aR,6R,8aS)-2,6,9,9-Tetramethyl-3-phenyl-octahydro-benzo[e]pyrrolo[2,1-b][1,3]oxazin-1-one(235094-27-6)
• EPA Substance Registry System: (2S,3S,3aS,4aR,6R,8aS)-2,6,9,9-Tetramethyl-3-phenyl-octahydro-benzo[e]pyrrolo[2,1-b][1,3]oxazin-1-one(235094-27-6)

Safety Data

• Hazardous Substances Data: 235094-27-6(Hazardous Substances Data)

Upstream product

• 235094-12-9 (2S,4aS,7R,8aR)-4,4,7-Trimethyl-2-(phenyl-phenylselanyl-methyl)-octahydro-benzo[e][1,3]oxazine 
• 82737-11-9 (+/-)-2-phenylselenophenyacetaldehyde 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 235094-32-3 (3'S,4'S)-8-(3'-methyl-4'-phenylpyrrolidinyl)-menthol 

Relevant articles and documents

A novel approach to chiral, nonracemic pyrrolidines by 5-exo-trig diastereoselective radical cyclization on acrylamides derived from (-)-8- aminomenthol

α,β-Unsaturated amides supported on perhydro-1,3-benzoxazines derived from (-)-8-aminomenthol as chiral auxiliaries undergo regio- and stereoselective 5-exo-trig radical cyclization leading to diastereomeric five-membered lactams. These cyclization products are transformed into enantiopure 3,4-disubstituted pyrrolidines by reduction with aluminum hydride followed by removal of the menthol appendage.