2351-14-6

Basic information

• Product Name: 5-aminohexane-1,2,3,4,6-pentol
• Synonyms: 5-aminohexane-1,2,3,4,6-pentol
• CAS NO: 2351-14-6
• Molecular Formula: C6H15NO5
• Molecular Weight: 181.19
• Mol File: 2351-14-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 530.7°C at 760 mmHg
• Flash Point: 274.7°C
• Appearance: /
• Density: 1.506g/cm³
• Vapor Pressure: 1.78E-13mmHg at 25°C
• Refractive Index: 1.595
• PKA: 11.66±0.45(Predicted)
• CAS DataBase Reference: 5-aminohexane-1,2,3,4,6-pentol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-aminohexane-1,2,3,4,6-pentol(2351-14-6)
• EPA Substance Registry System: 5-aminohexane-1,2,3,4,6-pentol(2351-14-6)

Safety Data

• Hazardous Substances Data: 2351-14-6(Hazardous Substances Data)

Usage

General Description

5-aminohexane-1,2,3,4,6-pentol is a chemical compound with the molecular formula C6H15NO5. It is also known as D-lyxo-hexulose-1-amino-5-phosphate. 5-aminohexane-1,2,3,4,6-pentol is a sugar alcohol that contains an amino group. It is commonly used in biotechnology and pharmaceutical research as a starting material for the synthesis of various compounds, including potential drugs and bioactive molecules. 5-aminohexane-1,2,3,4,6-pentol has also shown potential as a chelating agent for metal ions and as an antioxidant, making it of interest for various industrial and medical applications. Additionally, this compound has been investigated for its potential role in the treatment of neurological disorders and metabolic diseases due to its ability to cross the blood-brain barrier and its effects on cellular metabolism.

InChI:InChI=1/C6H15NO5/c7-3(1-8)5(11)6(12)4(10)2-9/h3-6,8-12H,1-2,7H2

Upstream product

• 4271-28-7 2-acetylamino-2-deoxy-D-glucitol 
• 90-76-6 2-deoxy-2-amino glucose 
• 4229-38-3 2-acetamido-2-deoxy-β-D-glucopyranosylamine 
• 1948-54-5 D-galactosamine 
• 10486-91-6 2-acetamido-2-deoxy-D-galacticol 
• 10486-92-7 2-acetamido-2-deoxy-D-mannitol 
• 90-76-6 D-mannosamine 
• 72-87-7 N-acetyl-D-mannosamine 
• 7270-77-1 L-sorbopyranose 
• 72-87-7 N-acetyl-beta-D-galactosamine 
• 72-87-7 N-acetyl-D-galactosamine 
• 102039-77-0 N,N'-diacetylchitobiosamine 
• 16405-05-3 2-acetamido-1-N-(1-benzyloxy-N-benzyloxycarbonyl-4-L-aspartyl)-2-deoxy-β-D-glucopyranosylamine 
• 7512-17-6 N-Acetyl-D-glucosamine 

Downstream Products

• 56211-19-9 2-acetamido-2-deoxy-D-glucitol pentaacetate 
• 62362-40-7 mannojirimycin 
• 14278-76-3 2-(2,4-dinitro-anilino)-2-deoxy-D-galactitol 
• 14278-76-3 2-(2,4-dinitro-anilino)-2-deoxy-D-glucitol 

Relevant articles and documents

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Aminopolyols from Carbohydrates: Amination of Sugars and Sugar-Derived Tetrahydrofurans with Transaminases

Carbohydrates are the major component of biomass and have unique potential as a sustainable source of building blocks for chemicals, materials, and biofuels because of their low cost, ready availability, and stereochemical diversity. With a view to upgrading carbohydrates to access valuable nitrogen-containing sugar-like compounds such as aminopolyols, biocatalytic aminations using transaminase enzymes (TAms) have been investigated as a sustainable alternative to traditional synthetic strategies. Demonstrated here is the reaction of TAms with sugar-derived tetrahydrofuran (THF) aldehydes, obtained from the regioselective dehydration of biomass-derived sugars, to provide access to cyclic aminodiols in high yields. In a preliminary study we have also established the direct transamination of sugars to give acyclic aminopolyols. Notably, the reaction of the ketose d-fructose proceeds with complete stereoselectivity to yield valuable aminosugars in high purity.

Synthesis and PLA2-inhibitory properties of 2(R)-acetamido-alkylphosphomethanols with a variable aggregate anchor.

Acylamino inhibitors of 14 kDa-PLA2 were synthesized which differ in the moiety that is not bound into the enzyme's active site but immersed in the lipid aggregate when a ternary inhibitory complex is formed. Our results indicate that this part of the inhibitors does not significantly influence inhibitory properties as long the amphiphilic character is retained. So, inhibitory and biophysical properties should be variable independently.