23522-48-7Relevant academic research and scientific papers
A New Synthesis Strategy for Rhodanine and Its Derivatives
Pan, Zhenliang,An, Wankai,Wu, Lulu,Fan, Liangxin,Yang, Guoyu,Xu, Cuilian
, p. 1131 - 1134 (2021/05/25)
Rhodanine and its derivatives have been known as privileged structures in pharmacological research because of their wide spectrum of biological activities, but the synthesis method of rhodanine skeleton is limited. In this paper, not only rhodanine skeleton, but also N -aryl rhodanines can be directly prepared via the reaction of thioureas and thioglycolic acid in one step catalyzed by protic acid, which provides a new approach of the synthesis of rhodanine and its derivatives. The developed strategy is straightforward, efficient, atom economical, and convenient in good yields.
Barriers to internal rotation around the C-N bond in 3-(o-aryl)-5-methyl- rhodanines using NMR spectroscopy and computational studies. Electron density topological analysis of the transition states
Aydeniz, Yeliz,Oguz, Funda,Yaman, Arzu,Konuklar, Aylin Sungur,Dogan, Ilknur,Aviyente, Viktorya,Klein, Roger A.
, p. 2426 - 2436 (2007/10/03)
We have investigated the pairs of rotational isomers for six 3-(o-aryl)-5-methyl-rhodanines (Z = H, F, Cl, Br, OH, and CH3) using NMR spectroscopy and density functional theory (DFT) calculations. Electron density topological and NBO analysis h
