23530-43-0

Basic information

• Product Name: N,N-dimethyl-2-nitrobenzenesulfonamide
• Synonyms: N,N-dimethyl-2-nitrobenzenesulfonamide
• CAS NO: 23530-43-0
• Molecular Formula: C₈H₁₀N₂O₄S
• Molecular Weight: 230.241
• EINECS: -0
• Mol File: 23530-43-0.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N-dimethyl-2-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-nitrobenzenesulfonamide(23530-43-0)
• EPA Substance Registry System: N,N-dimethyl-2-nitrobenzenesulfonamide(23530-43-0)

Safety Data

• Hazardous Substances Data: 23530-43-0(Hazardous Substances Data)

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 124-40-3 dimethyl amine 

Downstream Products

• 54468-86-9 2-amino-N,N-dimethyl-benzenesulfonamide 
• 1022956-26-8 2-((2,5-dichloropyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide 
• 58656-16-9 2-(4-methoxyphenoxy)nitrobenzene 
• 4475-59-6 1-(4-fluorophenoxy)-2-nitrobenzene 
• 93974-08-4 1-fluoro-2- (2-nitrophenoxy)benzene 
• 56966-62-2 1-(2-nitrophenoxy)-4-bromobenzene 
• 2216-12-8 1-nitro-2-phenoxy-benzene 
• 3402-70-8 1-nitro-2-(p-tolyloxy)benzene 
• 54495-62-4 2-(3'-methylphenoxy)nitrobenzene 
• 54106-40-0 1-methyl-2-(2-nitrophenoxy)benzene 
• 60287-57-2 1,3-dimethyl-5-(2-nitrophenoxy)benzene 

Relevant articles and documents

AXL INHIBITOR FORMULATIONS

Formulations of Compound 1 or a pharmaceutically acceptable salt thereof are described. Also disclosed are capsules having a dry blended powder comprising Compound 1 or a pharmaceutically acceptable salt thereof. The Compound 1 or a pharmaceutically accep

Preparation method of N,N-dimethylsulfamide derivatives

The invention discloses a preparation method of N,N-dimethylsulfamide derivatives and belongs to the technical field of synthesis of medical compounds. The preparation method comprises the following steps: reacting gramine, a reactant with sulfonyl chloride groups and an alkaline substance with any one of solvents such as CH2Cl2, CH3COCH3 and CH3CN at a temperature of minus 15 DEG C to 80 DEG C for 24-48 hours so as to obtain the product, wherein the molar ratio of the gramine to the reactant to the alkaline substance is (1.0-2.0):(1.2-4.0):(1.5-6.0). The N,N-dimethylsulfamide derivatives can be simply and efficiently prepared withlow cost, and the yield is up to 70-98%.

INHIBITORS OF CYCLIN DEPENDNT KINASE 7 (CDK7)

The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.